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. 2020 Jun 2;61(8):1203–1220. doi: 10.1194/jlr.RA120000781

TABLE 3.

LPL-binding characteristics of ANGPTL proteins and complexes

ANGPTL Protein or Complex Kd (nM) Kon (1/Ms) Koff (1/s)
ANGPTL3 343.0 3.2 x 104 1.2 × 10−3
ANGPTL3/8 6.4 6.9 x 104 4.4 × 10−3
ANGPTL4 17.7 9.7 x 105 1.7 × 10−3
ANGPTL4/8 <0.001 4.8 x 104 <1 × 10−7

The Kd, Kon, and Koff for ANGPTL3, ANGPTL3/8, ANGPTL4, and ANGPTL4/8 binding to LPL were determined using bio-layer interferometry.