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LPL inhibition summary for ANGPTL3 versus ANGPTL3/8 and ANGPTL4 versus ANGPTL4/8 activity assays
| Enzyme | Substrate | ANGPTL Protein | IC50 (nM) | ANGPTL Complex | IC50 (nM) | Change Direction | Fold Change |
| LPL | BODIPY-TG | ANGPTL3 | 26 | ANGPTL3/8 | 0.14 | Increase | (+) 186 |
| LPL | BODIPY-TG | ANGPTL4 | 0.29 | ANGPTL4/8 | 37 | Decrease | (−) 128 |
| LPL | VLDL | ANGPTL4 | 0.44 | ANGPTL4/8 | 105 | Decrease | (−) 239 |
IC50 concentrations were determined for ANGPTL3 versus ANGPTL3/8 and ANGPTL4 versus ANGPL4/8 in LPL.
