Table III.

Various Scenarios to Test Node Sensitivity and Demonstrate AOPBN Capability

Scenario	Parameters	Posterior Probability of Steatosis
1. Sufficient Key Events	Fatty acid beta oxidation = FALSE Fatty acid influx = TRUE Lipogenesis = TRUE Fatty acid efflux = FALSE	99.0%
2. Molecular Initiating Events	FXR = FALSE PPAR-alpha = FALSE PPAR-gamma = TRUE LXR = TRUE Insulin receptor = TRUE	97.3%
3. Molecular Initiating Events + Fatty Acid Efflux	FXR = FALSE PPAR-alpha = FALSE PPAR-gamma = TRUE LXR = TRUE Insulin receptor = TRUE Fatty acid efflux = FALSE	98.8%
4. Sufficient Key Event Subset 1	Fatty acid beta oxidation = FALSE	66.0%
5. Sufficient Key Event Subset 2	Fatty acid beta oxidation = FALSE Fatty acid efflux = FALSE	96.8%
6. Sufficient Key Event Subset 3	Fatty acid beta oxidation = FALSE PPAR-gamma = TRUE	90.5%
7. Sufficient Key Event Subset 4	Fatty acid beta oxidation = FALSE Lipogenesis = TRUE	76.8%
8. Molecular Initiating Events Closest to Adverse Outcome	PPAR-gamma = TRUE Insulin receptor = TRUE LXR = TRUE	97.1%
9. Molecular Initiating Events Furthest from Adverse Outcome	FXR = FALSE PPAR-alpha = FALSE	67.3%
10. Molecular Initiating Events Closest to Adverse Outcome + Fatty Acid Efflux	PPAR-gamma = TRUE Insulin receptor = TRUE LXR = TRUE Fatty acid efflux = FALSE	98.5%