Table 2.
LncRNA associated with migration and invasion of laryngeal squamous cell carcinoma.
| lncRNA | Cells | Tissues | Expression in LSCCs | Related gene | Functional role | References (PMID) |
|---|---|---|---|---|---|---|
| lncRNA MALAT1 | Tu 686, Tu 177, AMC-HN-8, LSC-1, NHBEC | LSCC | Upregulated | Promote migration and invasion, promote tumor cell metastasis | 31837057/31792655/25257554 | |
| LINC00886 | Tu 686, AMC-HN-8, Tu 177, 293 T | LSCC | Downregulated | VEGFA/PI3K/AKT signaling pathway/EMT | Significantly reduced the migration and invasion of cells in vitro | 32111441 |
| LINC00467 | HN6, SCC25, HN4, Cal27, SCC4 | Upregulated | miR-299-5p/USP48 | Migration and EMT proc | 32159247 | |
| lncRNA miR143HG | UM-SCC-17A | LSCC | Downregulated | miR-21 | Inhibition of migration and invasion rate | 31872875 |
| lncRNA Dlx6-AS1 | HEp-2 | LSCC | Upregulated | miR-376c | Promote cell proliferation, cycle and invasion | 31814904 |
| lncRNA SSTR5-AS1 | AMC-HN-8, Tu 212, Tu 686, Tu 177 | LSCC | Downregulated | MLL3/H3K4me3 | Upregulate E-cadherin and inhibit EMT | 31196171 |
| lncRNA CCAT1 | HEp-2 | LSCC | Upregulated | E-cadherin/N-cadherin/Vimentin, LET-7/HMGA2/Myc | Promote HEp-2 cell migration and invasion | 27830017 |
| lncRNA UCA1 | AMC-HN-8 | LSCC | Upregulated | Promote the invasion and migration of LSCC | 30679991 | |
| lncRNA HOXA11-AS | AMC-HN-8, HEp-2 | LSCC | Upregulated | Downregulation could significantly inhibit the growth, migration, and invasion of LSCC cells | 29511452 | |
| LINC00668 | Tu 177, Tu 212, Tu 686, AMC-HN-8 | LSCC | Upregulated | Promote migration and invasion | 30415008 | |
| lncRNA RP11-169D4.1 | SNU-899, SNU-46 | LSCC | Downregulated | miR-205-5p/RP11-169D4.1/Cdh1/AKT signaling pathway | Reduced the ability of cell migration and invasion in vitro | 28534968 |
| lncRNA AC026166.2-001 | AMC-HN-8, TU-212 | Downregulated | miR-24-3p/p27 | Inhibit cell migration | 29463827/25243407 | |
| lncRNA FTH1P3 | HEp-2, Tu 212 | LSCC | Upregulated | Promote the migration and invasion of LSCC cells | 31142627 | |
| lncRNA OIP5-AS1 | 16HBE, AMC-HN-8, Tu 177 | LSCC | Upregulated | miR-204-5p/ZEB1 | Promote migration and invasion, promote EMT process | 32009213 |
| lncRNA MIR100HG | UM-SCC-17A | LSCC | Upregulated | miR-204-5p | Promote the migration and invasion of LSCC cells | 31114240 |
| lncRNA RGMB-AS1 | HEp-2, AMC-HN-8 | LSCC | Upregulated | miR-22/NLRP3 | Promote of LSCC cell invasion in vitro | 31351424 |
| lncRNA ANRIL | AMC-HN-8, SNU-899 | LSCC | Upregulated | miR-181a/Snai2 | Promote LSCC cell invasion, migration, and EMT, to promote apoptosis | 31667207 |
| lncRNA LINC00339 | Hep2, Tu 212 | LSCC | Upregulated | miR-145 | Promote LSCC cell invasion and EMT process | 30485513 |
| lncRNA LOC554202 | HEp-2 | LSCC | Upregulated | miR-31/RhoA | Promote the invasion of LSCC cells | 29737563 |
| lncRNA XIST | HEp-2, HEK293T | LSCC | Upregulated | miR-124/EZH2, miR-144/IRS1 | Promote migration and invasion | 31071316/31894287 |
| lncRNA PVT1 | Tu 686, Tu 177, LSC-1 | LSCC | Upregulated | miR-519d-3p | Promote LSCC cell migration | 30304557 |
| lncRNA MEG3 | HEp-2 | LSCC | Downregulated | Twist1/Vimentin | Promote cell migration, invasion and EMT process | 30915750 |
| lncRNA snaR | UM-SCC-17A | LSCC | Upregulated | TGF-β1 | Promote the migration and invasion of LSCC cells | 30506952 |
| lncRNA MIR155HG | Tu 686, Tu 177, AMC-HN-8, 293T | LSCC | Upregulated | miR-155-5p/Sox10 | Promote the progress of LSCC and EMT | 31081043 |
| lncRNA SNHG12 | AMC-HN-8 | LSCC | Upregulated | miR-129-5p/WWP1 | Increase the invasive ability of LSCC cells | 31348766 |
| lncRNA SNHG1 | AMC-HN-8, HEp-2 | LSCC | Upregulated | miR-375/YAP1/HIPPO signaling pathway | Increase in vivo metastasis | 30323965 |
| lncRNA Dlx6-AS1 | HEp-2 | LSCC | Upregulated | miR-376c | Promote cell proliferation, cycle and invasion | 31814904 |