Table 3.

LncRNA involved in the signal transduction network of laryngeal squamous cell carcinoma.

lncRNA	Cells	Tissues	Expression in LSCCs	Related gene	Functional role	References (PMID)
lncRNA UCA1	AMC-HN-8	LSCC	Upregulated	Wnt/β-catenin signaling	Activation of Wnt/β-catenin signaling pathway promotes proliferation, invasion, and migration of LSCC cells	30679991
lncRNA NEF	UM-SCC-17A	LSCC	Downregulated	Wnt/β-catenin signaling	Inhibition of Wnt/β-catenin signaling pathway inhibits the proliferation of LSCC and promotes apoptosis	31186702
lncRNA DGCR5	HEp-2		Upregulated	miR-506/Wnt/β-catenin signaling	Promote CSC-like phenotype	30980388
lncRNA XIST	HEp-2, HEK293T	LSCC	Upregulated	miR-144/IRS1/PI3K/AKT signaling	Promote the ability of proliferation, colony formation, migration, and invasion	31894287
LINC00886	Tu 686, AMC-HN-8, Tu 177, 293 T	LSCC	Downregulated	VEGFA/PI3K/AKT signaling pathway/EMT	Overexpression significantly reduced cell proliferation, migration and invasion in vitro, and inhibited tumor growth in vivo	32111441
lncRNA RP11-169D4.1	SNU-899, SNU-46	LSCC	Downregulated	miR-205-5p/RP11-169D4.1/Cdh1/AKT signaling pathway	Reduced the ability of cell migration and invasion in vitro	28534968
lncRNA AC026166.2-001	AMC-HN-8, TU-212		Downregulated	miR-24-3p/p27/PI3K/AKT signaling	It can inhibit the proliferation and promote apoptosis of LSCC cells in vitro and in vivo	29463827/25243407
lncRNA SNHG1	AMC-HN-8, HEp-2	LSCC	Upregulated	miR-375/YAP1/HIPPO signaling pathway	Promote growth and transfer in vivo	30323965
lncRNA MIR155HG	Tu 686, Tu 177, AMC-HN-8, 293T	LSCC	Upregulated	miR-155-5p/TGF-β1/Sox10/TGF‐β signaling	Promote the progress of LSCC and EMT	31081043
lncRNA snaR	UM-SCC-17A	LSCC	Upregulated	TGF-β1/TGF-β signaling	Promote the proliferation, migration, and invasion of LSCC cells	30506952