Table 1.
Patient Demographics
| Demographic | ND | D |
P Value |
|||
|---|---|---|---|---|---|---|
| Severe Asthma | COPD | Bronchiectasis | ND vs. D | D vs. D | ||
| n | 13 | 11 | 15 | 15 | ||
| Age, yr | 34 ± 8 | 70 ± 17 | 70 ± 9 | 64 ± 15 | <0.001 | 0.472 |
| Sex | 0.528 | 0.012 | ||||
| M | 62% (8) | 73% (8) | 100% (15) | 53% (8) | ||
| F | 38% (5) | 27% (3) | 0% (0) | 47% (7) | ||
| BMI, kg/m2 | 23 ± 3 | 27.9 ± 8 | 21.7 ± 8 | 18.4 ± 6 | 0.237 | 0.009 |
| FEV1 % predicted | 109 ± 14 | 72 ± 14 | 45 ± 13 | 65 ± 20 | <0.001 | 0.005 |
| Disease severity* | ||||||
| Mild | — | 0% (0) | 7% (1) | 6% (1) | — | 0.797 |
| Moderate | — | 27% (3) | 40% (6) | 27% (4) | — | — |
| Severe | — | 73% (8) | 53% (8) | 67% (10) | — | — |
| Exacerbations in year preceding study recruitment | 0 ± 0 | 0 ± 1.5 | 3 ± 3 | 2 ± 1 | 0.032 | 0.013 |
| Smoking status | <0.001 | <0.001 | ||||
| Never-smoker | 100% (13) | 91% (10) | 0% (0) | 67% (10) | ||
| Ex-smoker | 0% (0) | 0% (0) | 47% (7) | 27% (4) | ||
| Current smoker | 0% (0) | 9% (1) | 53% (8) | 7% (1) | ||
| Antibiotic use in 6 mo preceding recruitment | 0.050 | <0.001 | ||||
| Yes | 0% (0) | 0% (0) | 67% (10) | 20% (3) | ||
| No | 100% (13) | 100% (11) | 33% (5) | 80% (12) | ||
| Inhaled corticosteroid use | ||||||
| Yes | — | 100% (11) | 53% (8) | 53% (8) | — | 0.064 |
| No | — | 0% (0) | 47% (7) | 47% (7) | — | — |
| Inhaled bronchodilator use | ||||||
| Yes | — | 100% (11) | 100% (15) | 53% (8) | — | 0.009 |
| No | — | 0% (0) | 0% (0) | 47% (7) | — | — |
Definition of abbreviations: ACT = Asthma Control Test; BMI = body mass index; BSI = Bronchiectasis Severity Index; COPD = chronic obstructive pulmonary disease; D = diseased; GOLD =Global Initiative for Chronic Obstructive Lung Disease; ND = nondiseased.
Demographic data is presented as median values ± interquartile range or percentages (patient numbers) as appropriate. Significant P values (P < 0.05) are bolded.
*
Defined according to disease-specific criteria. Severe asthma: ACT score; ≥20 = mild, 19–15 = moderate, <15 = severe. COPD: GOLD stage; 1 = mild, 2 = moderate, ≥3 = severe. Bronchiectasis: BSI; 0–4 = mild, 5–8 = moderate, ≥9 = severe.