Table 2.
Genes of the Core Resistome (n = 18) Identified across Study Cohorts
| Gene Name | Drug Class | Resistance Mechanism |
|---|---|---|
| aac (3)-VIIa | Aminoglycoside | Antibiotic inactivation |
| aph (3)-IIIa | Aminoglycoside | Antibiotic inactivation |
| oxa-255 | Cephalosporin, penam (β-lactam) | Antibiotic inactivation |
| cfxA2 | Cephamycin (β-lactam) | Antibiotic inactivation |
| dfrA1 | Diaminopyrimidine | Antibiotic target replacement |
| pmrA | Fluoroquinolone | Antibiotic efflux |
| mel (msrD) | Macrolide, lincosamide, streptogramin, tetracycline, phenicol, oxazolidinone, pleuromutilin | Antibiotic target protection |
| ermB | Macrolide, lincosamide, streptogramin | Antibiotic target alteration |
| ermF | Macrolide, lincosamide, streptogramin | Antibiotic target alteration |
| ermX | Macrolide, lincosamide, streptogramin | Antibiotic target alteration |
| lnuC | Lincosamide | Antibiotic inactivation |
| efrB | Rifamycin, macrolide, fluoroquinolone | Antibiotic efflux |
| catS | Phenicol | Antibiotic inactivation |
| tetA (46) | Tetracycline | Antibiotic efflux |
| tetW | Tetracycline | Antibiotic target protection |
| tetB (46) | Tetracycline | Antibiotic efflux |
| tet(D) | Tetracycline | Antibiotic efflux |
| tetO | Tetracycline | Antibiotic target protection |