Table 2.
Baseline and 12-Month Serum Concentrations of Vitamin D3 and Its Metabolites and Metabolite-to-Parent Compound Molar Ratios by Disease Status
| Control Subjects [Median (IQR)] (n = 57) | Asthma (n = 19) |
COPD (n = 17) |
|||
|---|---|---|---|---|---|
| Median (IQR) | P Value* | Median (IQR) | P Value† | ||
| Baseline | |||||
| Vitamin D3, nmol/L | 0.07 (0.07–1.21) | 3.25 (2.44–4.14) | <0.001 | 2.54 (1.37–5.49) | <0.001 |
| 25(OH)D3, nmol/L | 52.28 (32.11–70.30) | 43.79 (30.97–71.74) | 0.97 | 27.23 (15.47–62.37) | 0.03 |
| 1α,25(OH)2D3, pmol/L | 42.49 (1.87–76.50) | 88.33 (70.02–117.70) | <0.001 | 77.27 (36.53–99.18) | 0.04 |
| 24R,25(OH)2D3, nmol/L | 2.72 (0.98–4.24) | 2.27 (1.21–3.87) | 0.93 | 1.47 (0.87–3.51) | 0.33 |
| 4β,25(OH)2D3, pmol/L | 120.73 (72.65–191.38) | 146.75 (85.80–230.14) | 0.48 | 63.25 (1.70–170.37) | 0.04 |
| 25(OH)D3-to-vitamin D3 ratio | 166.51 (38.07–700.67) | 13.81 (8.86–30.73) | <0.001 | 10.49 (6.91–13.54) | <0.001 |
| 1α,25(OH)2D3-to-25(OH)D3 ratio × 103 | 0.79 (0.12–1.42) | 1.91 (1.23–2.75) | <0.001 | 2.04 (0.80–4.39) | 0.005 |
| 24R,25(OH)2D3-to-25(OH)D3 ratio | 0.05 (0.03–0.07) | 0.05 (0.03–0.06) | 0.72 | 0.06 (0.05–0.08) | 0.23 |
| 4β,25(OH)2D3-to-25(OH)D3 ratio × 103 | 2.33 (1.84–3.99) | 3.14 (2.18–3.49) | 0.50 | 2.09 (0.11–3.85) | 0.23 |
| 12 mo | |||||
| Vitamin D3, nmol/L | 1.22 (0.07–3.20) | 4.29 (2.68–6.64) | 0.001 | 3.71 (2.37–6.23) | 0.006 |
| 25(OH)D3, nmol/L | 91.02 (59.69–108.57) | 78.00 (63.03–91.74) | 0.44 | 62.94 (39.18–86.58) | 0.10 |
| 1α,25(OH)2D3, pmol/L | 74.35 (16.47–126.54) | 126.54 (87.81–150.11) | <0.001 | 84.13 (57.20–115.69) | 0.25 |
| 24R,25(OH)2D3, nmol/L | 5.72 (2.90–8.57) | 5.62 (3.67–7.42) | 0.83 | 4.31 (3.03–6.98) | 0.36 |
| 4β,25(OH)2D3, pmol/L | 262.07 (86.84–396.76) | 248.97 (139.60–298.14) | 0.76 | 201.72 (71.12–274.83) | 0.27 |
| 25(OH)D3-to-vitamin D3 ratio | 66.26 (26.10–419.32) | 18.68 (12.08–25.67) | <0.001 | 14.30 (10.91–22.06) | <0.001 |
| 1α,25(OH)2D3-to-25(OH)D3 ratio ×103 | 0.72 (0.27–0.89) | 1.58 (1.18–2.25) | <0.001 | 1.18 (0.88–2.55) | 0.003 |
| 24R,25(OH)2D3-to-25(OH)D3 ratio | 0.06 (0.04–0.08) | 0.07 (0.06–0.08) | 0.25 | 0.07 (0.05–0.09) | 0.30 |
| 4β,25(OH)2D3-to-25(OH)D3 ratio ×103 | 2.66 (1.64–3.95) | 2.77 (2.24–3.82) | 0.59 | 2.95 (1.83–3.68) | 0.93 |
Definition of abbreviations: 1α,25(OH)2D3 = 1α,25-dihydroxyvitamin D3; 4β,25(OH)2D3 = 4β,25-dihydroxyvitamin D3; 24R,25(OH)2D3 = 24R,25-dihydroxyvitamin D3; 25(OH)D3 = 25-hydroxyvitamin D3; COPD = chronic obstructive pulmonary disease; IQR = interquartile range.
*
P value from Mann-Whitney test comparing values for asthma versus control subjects.
†
P value from Mann-Whitney test comparing values for COPD versus control subjects.