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. 2020 Aug 1;202(3):371–382. doi: 10.1164/rccm.201909-1867OC

Table 3.

Expression of Vitamin D Pathway Genes in Patients with Asthma and COPD versus Control Subjects

  Phenotype CYP2R1
 CYP3A4
 CYP3A5
 CYP27A1
 CYP24A1
 CYP27B1
 DBP
 DHCR7
 VDR
 RXRA
logFC P Value logFC P Value logFC P Value logFC P Value logFC P Value logFC P Value logFC P Value logFC P Value logFC P Value logFC P Value
Asthma                                          
 UBIOPRED                                          
  Endobronchial biopsy Asthma (n = 41) vs. control subjects (n = 26) N/A N/A 0.04 0.76 N/A N/A −0.01 0.96 0.13 0.36 N/A N/A N/A N/A N/A N/A 0.10 0.48 −0.16 0.21
  Endobronchial brushings Asthma (n = 54) vs. control subjects (n = 44) 0.05 0.56 0.18 0.03 0.17 0.05 0.00 0.98 −0.02 0.87 0.14 0.23 −0.01 0.95 0.15 0.19 0.22 0.01 −0.25 0.03
  Nasal brushings Asthma (n = 32) vs. control subjects (n = 25) 0.09 0.55 −0.19 0.14 −0.32 0.03 0.30 0.06 −0.32 0.05 N/A N/A 0.19 0.19 0.10 0.52 0.37 0.01 0.11 0.46
  Blood Asthma (n = 165) vs. control subjects (n = 87) −0.02 0.71 0.00 0.95 −0.32 <0.0001 0.11 0.17 −0.05 0.55 −0.05 0.53 0.03 0.64 −0.07 0.30 0.01 0.86 0.05 0.52
  Sputum Asthma (n = 43) vs. control subjects (n = 16) 0.09 0.56 0.29 0.10 N/A N/A −0.26 0.08 N/A N/A N/A N/A N/A N/A N/A N/A 0.30 0.04 0.06 0.73
 ADEPT                                          
  Sputum Asthma (n = 39) vs. control subjects (n = 9) N/A N/A 0.03 0.90 N/A N/A −0.11 0.59 N/A N/A N/A N/A N/A N/A N/A N/A 0.05 0.80 0.19 0.36
 Woodruff                                          
  Blood Mild-moderate asthma (n = 23) vs. control subjects (n = 20) −0.10 0.41 0.05 0.46 −0.14 0.21 −0.19 0.38 0.12 0.24 0.03 0.73 0.03 0.80 0.02 0.72 −0.02 0.81 0.03 0.70
  Airway epithelium Mild-moderate asthma (n = 62) vs. control subjects (n = 43) 0.12 0.10 −0.08 0.03 −0.10 0.007 −0.17 0.02 −0.61 <0.001 0.06 0.12 −0.02 0.69 0.06 0.15 −0.05 0.16 −0.06 0.08
  Endobronchial biopsy Mild-moderate asthma (n = 37) vs. control subjects (n = 24) 0.14 0.14 −0.08 0.19 −0.17 0.19 −0.19 0.01 −0.41 0.015 0.04 0.57 0.13 0.17 0.10 0.12 0.09 0.10 −0.01 0.76
COPD                                          
 ECLIPSE                                          
  Blood COPD (n = 151) vs. control subjects (n = 47) 0.19 0.05 −0.18 0.07 N/A N/A 0.00 0.97 N/A N/A N/A N/A 0.06 0.52 N/A N/A −0.04 0.65 −0.17 0.05
  Sputum COPD (n = 104) vs. control subjects (n = 32) −0.06 0.54 −0.13 0.15 −0.11 0.33 0.13 0.27 −0.13 0.27 0.03 0.77 0.10 0.35 0.14 0.22 0.03 0.78 0.07 0.53
 Steiling                                          
  Airway epithelium Current/former smokers, COPD (n = 151) vs. control subjects (n = 87) 0.11 0.005 −0.01 0.80 0.24 <0.001 −0.28 <0.001 −0.08 0.42 0.04 0.07 −0.01 0.83 0.06 0.22 0.01 0.84 −0.04 0.19
 Tilley                                          
  Small airway epithelium Current smokers, COPD (n = 36) vs. control subjects (n = 72) 0.13 0.06 −0.01 0.92 0.23 <0.001 0.07 0.38 −0.22 0.18 0.06 0.18 −0.07 0.36 −0.02 0.79 0.11 0.06 −0.09 0.035
 Lung Tissue Research Consortium (GSE47460)                                          
  Lung homogenate COPD (n = 215) vs. control subjects (n = 105) −0.11 0.002 N/A N/A −0.52 <0.001 N/A N/A 0.36 0.06 0.19 0.09 0.29 0.005 0.08 0.15 0.15 0.008 −0.05 0.09

Definition of abbreviations: ADEPT = Airways Disease Endotyping for Personalized Therapeutics; COPD = chronic obstructive pulmonary disease; CYP = cytochrome P; DBP = vitamin D–binding protein; DHCR7 = 7-dehydrocholesterol reductase enzyme; ECLIPSE = Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points; logFC = log2 fold change; N/A = not available; RXRA = retinoid-X receptor-A; UBIOPRED = Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes; VDR = vitamin D receptor.