Table 4.

Expression of Vitamin D–Inducible Signatures in Patients with Asthma and COPD versus Control Subjects

	Phenotype	PBMC Signature		Epithelial Signature
		logFC	P Value	logFC	P Value
Asthma
UBIOPRED
Endobronchial biopsy	Asthma (n = 41) vs. control subjects (n = 26)	N/A	N/A	−0.04	0.43
Endobronchial brushings	Asthma (n = 54) vs. control subjects (n = 44)	N/A	N/A	0.00	0.90
Nasal brushings	Asthma (n = 32) vs. control subjects (n = 25)	N/A	N/A	0.10	0.04
Blood	Asthma (n = 165) vs. control subjects (n = 87)	0.06	0.03	N/A	N/A
Sputum	Asthma (n = 43) vs. control subjects (n = 16)	N/A	N/A	0.11	0.04
ADEPT
Sputum	Asthma (n = 39) vs. control subjects (n = 9)	N/A	N/A	0.18	0.01
Woodruff
Blood	Mild-moderate asthma (n = 23) vs. control subjects (n = 20)	0.00	0.99	N/A	N/A
Airway epithelium	Mild-moderate asthma (n = 62) vs. control subjects (n = 43)	N/A	N/A	0.07	0.053
Endobronchial biopsy	Mild-moderate asthma (n = 37) vs. control subjects (n = 24)	N/A	N/A	0.11	0.04
COPD
ECLIPSE
Blood	COPD (n = 151) vs. control subjects (n = 47)	−0.13	0.01	N/A	N/A
Sputum	COPD (n = 104) vs. control subjects (n = 32)	N/A	N/A	−0.01	0.79
Steiling
Airway epithelium	Current/former smokers, COPD (n = 87) vs. control subjects (n = 151)	N/A	N/A	0.03	0.20
Tilley
Small airway epithelium	Current smokers, COPD (n = 36) vs. control subjects (n = 72)	N/A	N/A	0.01	0.72
Lung Tissue Research Consortium (GSE47460)
Whole-lung homogenate	COPD (n = 215) vs. control subjects (n = 105)	N/A	N/A	−0.08	0.006

Definition of abbreviations: ADEPT = Airways Disease Endotyping for Personalized Therapeutics; COPD = chronic obstructive pulmonary disease; ECLIPSE = Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points; logFC = log₂ fold change; N/A = not applicable; PBMC = peripheral blood mononuclear cells; UBIOPRED = Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes.