Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 1;34(15-16):1039–1050. doi: 10.1101/gad.337691.120

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Reizel et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 3. — Adult ablation of FoxA factors reduces expression of key liver genes back to early developmental stages. (A) Expression of FoxA target genes is reduced back to the levels of early fetal stages following acute FoxA ablation. (Def.) Definitive. All gene expression levels are significantly lower in the FoxA-triple-null compared with hepatoblasts (adjusted P-value < 0.001) except for Arg1, Plg, and C1s. (B) The majority of FoxA-dependent genes in the adult liver are induced during liver development, and many are deactivated in the FoxA-triple-null liver back to total hepatoblast levels (adjusted P-value < 0.01) (for details, see the Materials and Methods). (TKO) FoxA-triple-null mutants. (C) Heat map demonstrating genes down-regulated back to hepatic or prehepatic stage in the FoxA-triple-null mutants.