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. 2020 Aug 3;39:148. doi: 10.1186/s13046-020-01650-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — COL4A1 knockdown inhibits the proliferation, migration and invasion of HCC cells. a Knockdown efficiency of COL4A1 using shRNA was confirmed by qRT-PCR and western blot in SMMC7721 cells and SK-Hep1 cells. b-d COL4A1 knockdown inhibited cell proliferation (b), migration (c) and invasion(d) by Real-time cell analyzer. e Downregulation of COL4A1 inhibited cell migration by wound healing assay. f COL4A1 knockdown inhibited cell proliferation by colony formation assay. g COL4A1 knockdown suppressed tumor growth in vivo. n = 7/group. Tumor volume was measured, and photographs of tumors were taken. Data are presented as means ± standard deviation. Student t test and Two-way ANOVA followed by Tukey’s multiple comparisons test, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001