Table 2.

Characteristics of ir-meningitis and management with steroids

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6	Patient 7
Severity grade of meningitis	3	2	1	2	1	2	1
Symptoms	Fever, confusion, partial seizure.	Headache, nausea, photophobia.	Headache, four limbs pain.	Headache, vomiting.	Headache, vomiting.	Headache, fever.	Fever, headache
Lumbar puncture
cells/mm3	40 (90% L)	8 (100% L)	19 (90% L)	25 (90% L)	0	9 (90% L)	320 (90% L)
Protein level	0.99 g/L	0.30 g/L	0.39 g/L	0.43 g/L	0.59 g/L	0.54 g/L	<0.45 g/L
Steroid treatment*
Initial dose	1 mg/kg/day	1 mg/kg/day	0	1 mg/kg/day	0	1 mg/kg	0
Length at full dose	7 days	7 days		7 days		14 days
Length of tapering	42 days	42 days		42 days		42 days
Delay of complete recovery
From irAE-N onset	18 days	17 days	10 days	21 days	65 days	49 days	10 days
From steroids onset	2 days	14 days	–	2 days	–	14 days	–
Other irAEs occurrence	None	None	None	Hypophysitis (gr. 2), diabetes (gr. 2), hepatitis (gr. 1)	None	Hypophysitis (gr. 2), hepatitis (gr. 4), colitis (gr. 2) small fibers neuropathy (gr.1)	None

*Prednisone equivalent doses.

irAE, immune-related adverse event; irAE-N, neurological immune-related adverse event; L, lymphocytes.