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. 2020 Jul 31;10(7):e038302. doi: 10.1136/bmjopen-2020-038302

Table 3.

Cox regression analysis of risk factors for TLR and TVR

Variables TLR TVR
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR 95% CI P value HR 95% CI P value HR 95% CI P value HR 95% CI P value
Age 1.001 0.985to 1.017 0.906 1.001 0.986 to 1.016 0.908
Male 1.094 0.686 to 1.742 0.707 1.178 0.749 to 1.852 0.479
Prior MI 0.973 0.695 to 1.363 0.875 0.997 0.725 to 1.372 0.987
Prior PCI 1.108 0.637to 1.927 0.718 1.155 0.687 to 1.940 0.587
Current smoking 0.981 0.096 to 1.383 0.913 1.009 0.729 to 1.397 0.958
Hypertension 1.082 0.761 to 1.539 0.66 1.025 0.736 to 1.429 0.883
Hyperlipidemia 0.901 0.571 to 1.423 0.655 0.972 0.623 to 1.515 0.899
Diabetes mellitus 0.973 0.675 to 1.404 0.885 1.026 0.727 to 1.448 0.885
BMI 0.968 0.918 to 1.019 0.216 0.966 0.919 to 1.015 0.169
LVEF 1.025 1.002 to 1.049 0.035 1.025 1.001 to 1.050 0.04 1.024 1.002 to 1.046 0.036 1.023 1.001 to 1.047 0.044
eGFR 0.995 0.998 to 1.002 0.141 0.997 0.991 to 1.003 0.333
Non-LAD CTO 1.733 1.188 to 2.529 0.004 1.441 0.977 to 2.124 0.065 1.873 1.301 to 2.697 <0.001 1.601 1.101 to 2.328 0.014
Reference vessel diameter 0.662 0.439 to 0.997 0.049 0.744 0.494 to 1.122 0.158 0.672 0.456 to 0.991 0.045 0.759 0.516 to 1.118 0.163
J-CTO score 1.271 1.009 to 1.601 0.042 1.279 1.018 to 1.607 0.035 1.247 1.000 to 1.556 0.05 1.254 1.007 to 1.561 0.043
SYNTAX score 1.039 1.020 to 1.059 <0.001 1.033 1.012 to 1.053 0.002 1.034 1.015 to 1.053 <0.001 1.026 1.006 to 1.046 0.01
Retrograde approach 1.888 0.769 to 4.637 0.166 1.713 0.699 to 4.199 0.239
Occlusion length ≥15 mm 1.753 1.233 to 2.492 0.002 1.539 1.033 to 2.293 0.034 1.671 1.200 to 2.328 0.002 1.476 1.012 to 2.151 0.043

Bold values are statistically significant (p<0.05).

BMI, body mass index; CTO, chronic total occlusion; eGFR, estimated glomerular filtration rate; J-CTO, multicenter CTO registry of Japan; LAD, left anterior descending; LVEF, left ventricular ejection fraction; MI, myocardial infarction; PCI, percutaneous coronary intervention; SYNTAX, synergy between percutaneous coronary intervention with taxus and cardiac surgery; TLR, target lesion revascularisation; TVR, target vessel revascularisation.