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. 2020 May 26;217(8):e20190673. doi: 10.1084/jem.20190673

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© 2020 Lin et al.

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Figure 2. — cDC1 maturation marker expression declines systemically during preinvasive neoplasia. Expression of maturation markers CD40, CD80, CD86, MHC II (I-A/I-E), and PD-L1 on cDC1s in the (A) pancreas/tumor, (B) ppLNs, (C) iLNs, and (D) spleen of healthy, PanIN-bearing, and tumor-bearing mice. Geometric mean fluorescence intensities (MFIs) shown. Samples were pooled across three to six mice per treatment group in B. Error bars indicate mean ± SD. ****, P < 0.0001; ***, P < 0.001; **, P < 0.01; *, P < 0.05 (one-way ANOVA with Tukey’s HSD post-test). Data shown are representative of four independent experiments with at least three mice per group.