Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 26;217(8):e20190133. doi: 10.1084/jem.20190133

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Babic et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 3. — NKG2D is associated with reinforced type 1 response gene signature in in vitro–generated Th1 and Th17 cells. (A–E) Transcriptome analysis of Th1 and Th17 (IL-1β, -6, -23, and IL-12*) cells sorted as NKG2D⁺ or Klrk1^−/−. (A) Principal component analysis of Th cell subsets based on differentially expressed genes for each of the comparisons (filtered for padj < 0.05, Mann–Whitney U test). Each dot represents an independent culture (n = 3). (B and C) Venn diagram showing number of transcripts (filtered for padj < 0.05; B) and scatter plot showing transcripts of genes differentially expressed in NKG2D⁺ and Klrk1^−/− cells (filtered for padj < 0.05 and FC >1.2; C) preferentially in Th1 (red), Th17 (blue), or both Th1 and Th17 lineages (purple). Gray dots represent the genes below the selected threshold. (D and E) Z-score heat maps showing relative expression of selected genes in the four T cell subsets. Selected genes are filtered for padj < 0.05 and FC >1.2 in at least one comparison.