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. 2020 Jun 2;217(8):e20191734. doi: 10.1084/jem.20191734

Figure S3.

Figure S3.

MN dendrites of mutSOD1 animals display age-dependent vacuolization. (A) Dendritic varicosities (unfilled arrowheads) in a WT MN at P51. (B) Dendritic varicosities (unfilled arrowheads) in a wtSOD1 MN at P98. (C) In mutSOD1 MNs, many varicosities display vacuoles (filled arrowheads). In contrast, dendritic varicosities do not display any vacuole in wtSOD1 MNs (B), indicating that the vacuoles do not result from the transgenes by themselves but are the consequence of the mutation. In mutSOD1 MNs, the vacuoles increase in size over time (C). Scale bars: 10 µm.