Table 5.
The KEGG pathway enrichment analysis of genes in each module
| KEGG term ID | Term description | FDR |
|---|---|---|
| Black module | ||
| hsa04668 | TNF signaling pathway | 0.0029 |
| hsa04610 | Complement and coagulation cascades | 0.0065 |
| hsa04621 | NOD-like receptor signaling pathway | 0.0068 |
| Blue module (top 10) | ||
| hsa04142 | Lysosome | 0.0015 |
| hsa04670 | Leukocyte transendothelial migration | 0.0015 |
| hsa04380 | Osteoclast differentiation | 0.0078 |
| hsa05152 | Tuberculosis | 0.0078 |
| hsa00052 | Galactose metabolism | 0.0079 |
| hsa05140 | Leishmaniasis | 0.0136 |
| hsa04140 | Autophagy—animal | 0.0233 |
| hsa04666 | Fc gamma R-mediated phagocytosis | 0.0286 |
| hsa05161 | Hepatitis B | 0.032 |
| hsa05322 | Systemic lupus erythematosus | 0.032 |
| Green module | ||
| hsa04610 | Complement and coagulation cascades | 0.0028 |
| hsa05133 | Pertussis | 0.0132 |
| hsa04010 | MAPK signaling pathway | 0.0394 |
| Pink module | ||
| hsa05322 | Systemic lupus erythematosus | 0.0161 |
| Purple module | ||
| hsa04145 | Phagosome | 0.00051 |
| hsa00380 | Tryptophan metabolism | 0.0024 |
| hsa00340 | Histidine metabolism | 0.0176 |
| hsa04066 | HIF-1 signaling pathway | 0.0176 |
| hsa04640 | Hematopoietic cell lineage | 0.0176 |
| hsa04216 | Ferroptosis | 0.0327 |
| hsa00480 | Glutathione metabolism | 0.0396 |
| hsa04979 | Cholesterol metabolism | 0.0396 |
| Turquoise module (top 10) | ||
| hsa05167 | Kaposi’s sarcoma-associated herpesvirus infection | 2.06E−05 |
| hsa05161 | Hepatitis B | 4.52E−05 |
| hsa05162 | Measles | 0.00013 |
| hsa05164 | Influenza A | 0.00013 |
| hsa05321 | Inflammatory bowel disease (IBD) | 0.00024 |
| hsa05140 | Leishmaniasis | 0.00042 |
| hsa04620 | Toll-like receptor signaling pathway | 0.00045 |
| hsa04012 | ErbB signaling pathway | 0.00088 |
| hsa04660 | T cell receptor signaling pathway | 0.0019 |
| hsa04917 | Prolactin signaling pathway | 0.0019 |
| Yellow module | ||
| hsa05340 | Primary immunodeficiency | 4.86E−05 |
| hsa04060 | Cytokine-cytokine receptor interaction | 0.00079 |
| hsa04662 | B cell receptor signaling pathway | 0.00079 |
| hsa04640 | Hematopoietic cell lineage | 0.0018 |
| hsa04650 | Natural killer cell mediated cytotoxicity | 0.006 |
| hsa04659 | Th17 cell differentiation | 0.0143 |
| hsa04660 | T cell receptor signaling pathway | 0.0143 |
| hsa04514 | Cell adhesion molecules (CAMs) | 0.0455 |
| hsa04658 | Th1 and Th2 cell differentiation | 0.0493 |