Table 1.

A summary of the cell types that express SR-B1, and their functions pertaining to the pathology of stroke and other neurological disorders

Cell type	Function	Reference
Epithelial cells	- Upregulates wound tissue repair by affecting the proliferative and migratory properties of keratinocytes - Regulates ceramide levels and maintain barrier function of keratinocytes - Vitamin E uptake might be regulated by SR-B1 in pneumocytes - Functions as plasma membrane cholesterol sensor	Muresan et al. [34], Muresan et al. [35], Kolleck et al. [36], Morel et al. [20]
Smooth muscle cells	- rHDL inhibits smooth muscle cell chemokine expression, p65, and proliferation through SR-B1 - HDL-associated lysosphinoglipids function to reduce ROS generation, which requires SR-B1 coordinate signaling	Van der Vorst et al. [37], Tolle et al. [38]
Monocytes	- Subclinical endotoxemia promotes atherosclerosis by converting monocytes into a persistent inflammatory state with reduced SR-B1	Geng et al. [39]
Macrophages	- SR-B1 invalidation reduces free-cholesterol-induced apoptosis and promotes atherosclerosis	Galle-Treger et al. [40]
Endothelial cells	- Functions as plasma membrane cholesterol sensor - Binding of SR-B1 with HDL activates endothelial NO synthase and stimulates endothelial cell migration - Apolipoprotein A-1 promotes endothelial repair through SR-B1 - SR-B1 acts as a mechanosensor in response to shear stress - SR-B1 is involved in transendothelial cholesterol transport	Saddar et al. [41], Yuhanna et al. 2001, Seetharam et al. [42], He et al. [43], Zhang et al. [44], Miao et al. [21]
Steroidogenic cells	- Estrogen increases brain SR-B1 levels - SR-B1 facilitates vasorelaxation pathway via interactions with DHEA-enriched HDL	Srivastava et al. [45], Paatela et al. [46]
Astrocytes	-Impairment of amyloid β uptake in Alzheimer’s correlated with a lower expression of SR-B1	Iram et al. [47]
Hepatocytes	- Mediates uptake of HDL-derived cholesterol ester	Acton et al. [17]