Table 2.

A detailed summary depicting the modifiable risk factors and their associated findings

SR-B1	Modifiable risk factors	Findings	References
Positive factors	Diet	- Mediterranean diet increases SR-B1 expression - SR-B1 has an important role in the uptake of lipid-soluble vitamins, which have been associated with lower risk of stroke - Chronic moderate alcohol accelerated cholesterol clearance via SR-B1-mediated reverse cholesterol transport	Nakamura et al. [52], Rimm et al. [53], Farras et al. [54], Han et al. [55] Li et al. [56]
	Exercise	- Increases SR-B1 expression	Wei et al. [57]
Negative factors	Smoking	- Smoking decreases SR-B1 expression of keratinocytes and possibly type II pneumocytes	Kolleck et al. [36], Sticozzi et al. [58]
	Diabetes	- Increases SR-B1 expression - SR-B1-knockout hyperglycemic mice had an increased incidence of coronary artery atherothrombosis, myocardial infarction, and early death	Hayashi et al. [59], Gonzalez et al. [60]
	Obesity	- Obesity-induced upregulation of miR-24 could function as a feedback regulator of SR-B1	Wang et al. [61]
	Hypercholesterolemia/atherosclerosis	- SR-B1 primarily functions in an atheroprotective capacity, when expressed in monocytes and macrophages	Kozarsky et al. [62], Zhang et al. [63], Van Eck et al. [64], Galle-Treger et al. [40]
	Coronary heart disease (CHD)	- SR-B1 deficiency leads to increased risk of CHD.	Zanoni et al. [65]
	Hypertension	- Lack of direct studies investigating SR-B1 expression in hypertension - Indirect effects may be possible, as a lack of SR-B1 led to impairment of nitric oxide, a potent vasodilator	Pearson et al. [66], Hermann et al. [67]
	Sickle cell	- No direct studies involving SR-B1 expression and sickle cell conditions - Indirect involvement is possible, as lipid dysregulation partially determines severity of sickle cell - SR-B1 is reported to facilitate cell-entry of malaria	Akinlade et al. [68], Rodrigues et al. [69]