Table 1.

Prevalence of autoreactivity in patients with atopic dermatitis categorized by age

Patients with atopic dermatitis	Severity of AD/population	Prevalence of IgE autoreactivity in AD	Prevalence of IgE autoreactivity in control subjects	References
Children 0–1 year	Mild–severe	20.0% (1/5)	/	Natter et al. [19]
	Moderate–severe	15.0% (25/60)	/	Mothes et al. [20]
Children 2–13 years	Mild–severe	16.7% (1/6)	/	Natter et al. [19]
	Moderate–severe	80.0% (16/20)	/	Mothes et al. [20]
Adolescents 14–23 years	Mild–severe	63.6% (7/11)	/	Natter et al. [19]
	EASI: 10–39.4	50.0% (2/4)	/	Mitterman et al. [38]
Adults ≥ 24 years	/	60.0% (12/20)	0.0% (0/2)	Valenta et al. [17]
	Mild–severe	44.8% (13/29)	/	Natter et al. [19]
	/	62.5% (10/16)	0% (0/1)	Ochs et al. [57]
	/	2.5% (1/40) SART2161	4.9% (2/41) SART2161	Kawamoto et al. [30]
	/	37.5% (15/40) SART109	29.3% (12/41) SART109
	/	15% (6/40) SART315	17.1% (7/41) SART315
	/	27.5% (11/40) CypB84	29.3% (12/41) CypB84
	/	17.5% (7/40) CypB91	31.7% (13/41) CypB91
	/	10% (4/40) ART475	12.2% (5/41) ART475	Kinaciyan et al. [53]
	Mild	100.0% (1/1)	/	Kortekangas-Savolainen [33]
	/	37.0% (10/27)	/	Aichberger et al. [37]
	/	91.7% (11/12)	0.0% (0/6)	Mothes et al. [20]
	/	23.0% (40/174)	/	Schmid-Grendelmeier et al. [34]
	EASI: 0.6–39.4	42.0% (29/69)	/	Tanaka et al. [55]
	Mild–severe	77.0% (47/61)	8.7% (4/46)	Mitterman et al. [38]
	EASI: 4.4–59.8	85.7% (6/7)	0.0% (0/12)	Altrichter et al. [35]
	EASI: 0.6–39.4	28.0% (54/192)	/	Zeller et al. [36]
	SCORAD: 21.93–71.36	71.8% (51/71)	0.0% (0/36)	Watanabe et al. [31]
	/	14.8% (9/61)	/	Aichberger et al. [37]
	/	91.7% (11/12)	0.0% (0/6)	Lucae et al. [91]
	Moderate–severe	100% (4/4)	/	Roesner et al. [106]
	/	91.7% (11/12)	/

Percentage of IgE autoreactivity in atopic dermatitis with the severity of the disease compared with healthy subjects, subdivided into children 0–1 year, 2–13 years, adolescents and adults