Table 3.

Distribution of down-regulated proteins in GO secondary annotations (T/C)

GO terms level 1	GO terms level 2	No. of proteins
Biological process	Cellular process	463
	Single-organism process	318
	Biological regulation	318
	Metabolic process	314
	Cellular component organization or biogenesis	191
	Response to stimulus	152
	Localization	131
	Multicellular organismal process	123
	Developmental process	121
	Signaling	77
	Multi-organism process	35
	Immune system process	34
	Biological adhesion	27
	Other	58
Cellular component	Cell	588
	Organelle	521
	Macromolecular complex	236
	Membrane	220
	Membrane-enclosed lumen	198
	Extracellular region	193
	Cell junction	65
	Supramolecular complex	45
	Other	17
Molecular function	Binding	506
	Catalytic activity	180
	Structural molecule activity	55
	Molecular function regulator	46
	Nucleic acid binding transcription factor activity	17
	Transporter activity	17
	Transcription factor activity, protein binding	16
	Signal transducer activity	10
	Other	27