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. 2020 Aug 3;20:17. doi: 10.1186/s12861-020-00222-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Focal abnormalities of N-cadherin expression in the neural folds of p120fl/fl;Wnt1Cre mutant mice. a-h Immunofluorescence of p120ctn (left panels) and N-cadherin (right panels; nuclear counterstaining by DAPI) on neural folds/tube in the hindbrain region of young embryos (lateral sides of folds are annotated by arrowheads). Detection was on 8-somite (a, b) and 12-somite (e, f) control embryos, and on 10-somite (c, d) and 12-somite (g, h) mutant embryos. The mutant embryos showed focal loss of both p120ctn and N-cadherin at the very tip of the neural folds (arrows in c, d, g, h), but in the 12-somite mutant embryo the p120ctn-lacking lateral side of the neural folds retained strong N-cadherin positivity (arrowheads in g, h). Scale bar: 20 μm. i-q IHC of p120ctn (i-k) and of N-cadherin (l-n) on neural folds/tube in the hindbrain region of 18–22 somite embryos. Scale bars: 20 μm. o-q Immunofluorescence of N-cadherin in areas, corresponding to the squares in panels l-n. The embryos analysed were control (i, l, o), mutant with closed neural tube (j, m, p) and mutant with NTD (k, n, q). p120ctn-lacking neural folds/tube (arrows in j, k) retained N-cadherin positivity (m, n, p, q) although N-cadherin was locally aggregated in case of NTD (n, arrows in q)