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. 2020 Jul 29;583(7818):752–759. doi: 10.1038/s41586-020-2119-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, Number of feDMRs predicted in each tissue from each stage. b, Positive rate in E11.5 tissues of elements that were experimentally validated as an enhancer (+) or not (−) in a given E11.5 tissue. Numbers indicate the number of VISTA elements. c, Positive rate (fraction of elements that are experimentally validated as enhancer in a given tissue) of DNA elements in VISTA enhancer browser (left), ones that do not overlap with feDMRs or H3K27ac peaks (middle), and those that do not overlap with feDMRs or H3K27ac peaks and do not show a high evolutionary PhyloP score (right). Numbers in parentheses indicate the number of VISTA elements. d, Left, percentage of putative enhancers from ref. ²³ that overlap with feDMRs in each tissue sample. Right, percentage of feDMRs that overlap with putative enhancers from ref. ²³.