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. 2018 Jul 2;4:15. doi: 10.1186/s41016-018-0123-x

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Kaplan-Meier curves demonstrating unfavorable hemorrhage-free survival difference between bAVMs with and without certain morphologic features. a There was a significant difference between the time to unfavorable hemorrhage for patients with periventricular and non-periventricular bAVMs (log-rank, P = .002). b There was also a significant difference between the time to unfavorable hemorrhage for patients with temporal location and non-temporal bAVMs (log-rank, P = .03). c Children with non-temporal bAVMs tended to present unfavorable hemorrhage earlier than non-temporal lobe bAVMs (log-rank, P = .08). d The unfavorable-hemorrhage free survival was similar in children with or without one biomarker. In contrast, children harboring two or more biomarkers were at higher risk for early unfavorable hemorrhage (log-rank, P < .001). bAVMs were further classified into four types with these features. e Children with Type Ia and Ib lesions presented with unfavorable hemorrhage earlier than those with Type II lesions (log-rank, P < .001)