Table 2.

Differentially expressed miRNAs (p < 0.05) screened out in microarray study

	miRNA	p	FC (B/A)	R	FC (C/A)	R	FC (D/A)	R
1	hsa-miR-3198	0.000	− 10.41	Down	− 8.81	Down	− 10.18	Down
2	hsa-miR-4314	0.000	− 18.91	Down	− 16.00	Down	− 18.48	Down
3	hsa-miR-425	0.000	1.02	Up	− 59.68	Down	1.07	Up
4	hsa-miR-148b	0.000	2.49	Up	− 7.22	Down	3.21	Up
5	hsa-miR-27a	0.000	1.10	Up	− 149.85	Down	1.23	Up
6	hsa-miR-140-3p	0.000	1.05	Up	− 24.44	Down	− 1.03	Down
7	hsa-miR-101	0.000	2.51	Up	− 15.00	Down	1.77	Up
8	hsa-miR-550a	0.000	− 1.86	Down	− 1.57	Down	− 1.81	Down
9	hsa-miR-148a	0.000	1.74	Up	− 41.09	Down	− 1.24	Down
10	hsa-miR-151-5p	0.000	1.24	Up	− 27.05	Down	1.13	Up
11	hsa-miR-4322	0.000	− 3.53	Down	− 1.98	Down	− 3.44	Down
12	hsa-miR-4286	0.000	− 2.02	Down	− 1.71	Down	− 1.10	Down
13	hsa-miR-3945	0.000	− 7.44	Down	− 6.29	Down	− 7.27	Down
14	hsa-miR-3131	0.000	− 9.32	Down	− 7.89	Down	− 9.10	Down
15	hsa-miR-936	0.000	− 4.34	Down	− 17.62	Down	− 20.36	Down
16	hsa-miR-654-5p	0.000	− 1.74	Down	− 1.48	Down	− 1.70	Down
17	hsa-miR-516b	0.000	− 2.33	Down	− 1.97	Down	− 2.28	Down
18	hsa-miR-139-3p	0.000	− 2.62	Down	− 2.95	Down	− 3.41	Down
19	hsa-miR-4253	0.000	− 4.70	Down	− 9.40	Down	− 10.86	Down
20	hsa-miR-516a-5p	0.000	− 3.65	Down	− 4.08	Down	− 4.71	Down
21	hsa-miR-23b	0.000	1.10	Up	− 17.34	Down	− 1.93	Down
22	hsa-miR-140-5p	0.000	− 2.64	Down	− 44.00	Down	− 1.05	Down
23	hsa-miR-363	0.000	1.54	Up	− 16.54	Down	− 2.20	Down
24	hsa-miR-3679-5p	0.000	1.00	Up	1.91	Up	1.36	Up
25	hsa-miR-19a	0.000	1.21	Up	− 52.68	Down	1.14	Up
26	hsa-miR-342-3p	0.000	− 1.40	Down	− 27.97	Down	− 3.55	Down
27	hsa-miR-199a-5p	0.001	3.64	Up	− 1.89	Down	9.24	Up
28	hsa-miR-27b	0.001	3.27	Up	− 13.00	Down	− 1.10	Down
29	hsa-miR-130b	0.001	3.23	Up	− 5.25	Down	2.75	Up
30	hsa-miR-199a-3p	0.002	− 1.09	Down	− 42.84	Down	1.18	Up
31	hsa-miR-202	0.003	− 2.31	Down	− 28.26	Down	− 1.57	Down
32	hsa-miR-29a	0.004	1.43	Up	− 24.44	Down	1.07	Up
33	hsa-miR-3194	0.005	− 1.95	Down	− 28.97	Down	− 16.38	Down
34	hsa-miR-338-3p	0.005	1.11	Up	− 6.21	Down	2.57	Up
35	hsa-miR-187*	0005	− 2.60	Down	− 7.60	Down	− 8.78	Down
36	hsa-miR-4271	0.005	− 1.35	Down	1.46	Up	− 1.16	Down
37	hsa-miR-548q	0.006	− 5.43	Down	− 22.20	Down	− 16.55	Down
38	hsa-miR-1914*	0.006	− 19.0	Down	− 29.14	Down	− 6.34	Down
39	hsa-miR-221	0.008	1.24	Up	− 10.62	Down	1.40	Up
40	hsa-miR-29b	0.008	4.18	Up	− 2.41	Down	− 1.33	Down
41	hsa-miR-26b	0.008	− 1.09	Down	− 50.92	Down	− 1.58	Down
42	hsa-miR-494	0.008	− 1.79	Down	5.18	Up	− 1.83	Down
43	hsa-miR-3162	0.008	− 1.26	Down	1.39	Up	− 1.00	Down
44	hsa-miR-29c	0.009	2.01	Up	− 17.16	Down	1.63	Up
45	hsa-miR-186	0.009	1.49	Up	− 6.31	Down	− 2.08	Down
46	hsa-miR-107	0.011	1.25	Up	− 21.56	Down	1.07	Up
47	hsa-miR-150	0.011	− 2.59	Down	− 48.16	Down	− 11.70	Down
48	hsa-miR-1226*	0.011	− 5.79	Down	− 18.30	Down	− 6.71	Down
49	hsa-miR-1246	0.013	− 2.39	Down	− 74.43	Down	− 2.40	Down
50	hsa-miR-30b	0014	1.23	Up	− 6.65	Down	1.20	Up
51	hsa-miR-486-5p	0.014	1.28	Up	2.81	Up	1.10	Up
52	hsa-miR-30c	0.015	2.62	Up	− 4.79	Down	− 1.20	Down
53	hsa-miR-92a	0.016	1.29	Up	1.90	Up	1.13	Up
54	hsa-miR-1290	0.017	− 2.82	Down	− 24.13	Down	− 2.55	Down
55	hsv1-miR-H17	0.017	− 1.72	Down	− 2.01	Down	− 1.64	Down
56	hsa-miR-126	0.018	1.39	Up	− 22.40	Down	1.26	Up
57	hsa-miR-185	0.019	1.76	Up	− 12.72	Down	1.77	Up
58	hsa-miR-1268	0.019	− 1.55	Down	− 1.35	Down	− 1.26	Down
59	hsa-miR-765	0.022	− 1.42	Down	1.46	Up	− 1.14	Down
60	hsa-miR-4298	0.022	− 1.41	Down	1.06	Up	1.10	Up
61	hsa-miR-1471	0.022	− 26.60	Down	− 7.22	Down	− 9.89	Down
62	hsa-miR-324-3p	0.024	1.66	Up	− 4.00	Down	− 1.42	Down
63	hsa-miR-130a	0.025	2.40	Up	− 7.23	Down	2.36	Up
64	hsa-miR-21	0.027	1.51	Up	− 2.31	Down	1.25	Up
65	hsa-miR-451	0.027	1.29	Up	− 6.10	Down	1.02	Up
66	hsa-miR-20b	0.028	1.50	Up	− 11.22	Down	− 1.11	Down
67	hsa-miR-2861	0.032	− 1.35	Down	− 1.06	Down	− 1.42	Down
68	hsa-miR-17	0.037	1.56	Up	− 8.64	Down	1.31	Up
69	hsa-miR-4327	0.038	− 2.00	Down	1.41	Up	− 1.51	Down
70	hsa-miR-3937	0.041	− 1.22	Down	− 8.01	Down	− 1.21	Down
71	hsa-miR-1260b	0..046	− 1.50	Down	− 1.68	Down	− 1.95	Down
72	hsa-miR-30e	0.046	2.08	Up	− 7.18	Down	1.41	Up
73	hsa-miR-940	0.046	1.49	Up	4.47	Up	1.18	Up
74	hsa-miR-23a	0.048	− 1.01	Down	− 13.94	Down	− 1.10	Down
75	hsa-miR-484	0.049	− 2.27	Down	− 4.47	Down	− 3.27	Down
76	hsa-miR-19b	0.050	1.34	Up	− 3.20	Down	1.21	Up
77	hsa-miR-1224-5p	0.050	− 5.80	Down	− 11.82	Down	1.13	Up

p significant p value, FC absolute value of fold change, R regulation, up means upregulated compared with the control group and down means downregulated. *Low expression. It is a symbol based on naming rule of miRNA. As is revealed, 77 out of all the miRNAs probes have a significantly different expression level