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Multivariate analysis including standard prognostic factors and the effect of any longitudinal increase in serum MMP-9 in glioblastoma patients
| Variable | Glioblastoma (n = 164, 140 deaths) |
|
|---|---|---|
| HR (95% CI) | P | |
| Each doubling in MMP-9 value | 1.1 (0.9–1.2) | 0.11 |
| Age (per 10-year increase) | 1.3 (1.1–1.5) | 0.003 |
| Extent of resection | ||
| Gross total resection | 1 | 0.02 |
| Partial resection | 1.0 (0.7–1.5) | |
| Biopsy | 1.8 (1.2–2.8) | |
| Karnofsky performance scale | ||
| <70 | 1 | 0.91 |
| ≥70 | 0.9 (0.4–2.1) | |
