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. 2019 Dec 16;69(8):1502–1509. doi: 10.1136/gutjnl-2019-319057

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Adjusted NNT to prevent one LT or death according to treatment duration. The solid line represents the adjusted NNT with UDCA among patients with PBC to prevent one LT or death according to various treatment durations on the x-axis. The dotted lines represent the 95% CI, which are based on both the 95% CI of the adjusted HR of UDCA with respect to the occurrence of LT or death and 95% CI of the cumulative LT-free survival in patients without UDCA therapy. Results are adjusted for sex, age, year of diagnosis, albumin, platelet count, bilirubin, alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase. LT, liver transplantation; NNT, number needed to treat; PBC, primary biliary cholangitis; UDCA, ursodeoxycholic acid.