Table 1.
Summary of ‘credible positive associations’ from meta-analyses and credibility assessment
| Gene | Variant | Cases vs controls (number of samples) |
Allelic model | Power | Recessive model: var/var vs wt/wt and wt/var | Dominant model: wt/var and var/var vs wt/wt | Classification | ||||||||||||||
| N | Effect size | Heterogeneity | N | Effect size | Heterogeneity | Power | N | Effect size | Heterogeneity | Power | |||||||||||
| OR (95% CI) | P value | I2 (95% CI) | P value | OR (95% CI) | P value | I2 (95% CI) | P value | OR (95% CI) | P value | I2 (95% CI) | P value | ||||||||||
| MUTYH | rs36053993 | 28 302 vs 20 935 (19*) | 19 | 1.42 (1.22 to 1.66) | 4.89E-06 | 0 (0 to 33) | 0.703 | 0.99 | na | na | na | na | na | na | 19 | 1.31 (1.12 to 1.53) | 0.001 | 0 (0 to 24) | 0.837 | 0.88 | Positive |
| MUTYH | rs34612342 | 28 180 vs 20 923 (19*) | 17 | 1.89 (1.47 to 2.42) | 5.72E-07 | 0 (0 to 62) | 0.828 | 1.00 | 7 | 3.40 (1.22 to 9.48) | 0.019 | 0 (0 to 0) | 0.998 | 1.00 | 17 | 1.80 (1.39 to 2.31) | 6.42E-06 | 0 (0 to 52) | 0.884 | 1.00 | Positive |
| SMAD7 | rs12953717 | 28 006 vs 26 539 (13*) | 13 | 1.11 (1.07 to 1.16) | 6.24E-07 | 49 (0 to 93) | 0.024 | 1.00 | 13 | 1.17 (1.08 to 1.26) | 8.34E-05 | 45 (0 to 94) | 0.041 | 1.00 | 13 | 1.14 (1.07 to 1.21) | 5.00E-05 | 54 (10 to 95) | 0.020 | 1.00 | Positive |
| SMAD7 | rs4464148 | 17 772 vs 17 356 (9*) | 9 | 1.12 (1.08 to 1.16) | 2.66E-09 | 12 (0 to 92) | 0.337 | 1.00 | 9 | 1.13 (1.00 to 1.28) | 0.054 | 49 (0 to 98) | 0.047 | 0.97 | 9 | 1.16 (1.11 to 1.21) | 2.09E-10 | 2 (0 to 86) | 0.416 | 1.00 | Positive |
| 8q24 | rs10505477 | 18 562 vs 20 132 (14) | 14 | 1.14 (1.10 to 1.19) | 2.04E-11 | 44 (0 to 82) | 0.040 | 1.00 | 14 | 1.16 (1.10 to 1.23) | 4.06E-07 | 35 (0 to 74) | 0.092 | 1.00 | 14 | 1.24 (1.17 to 1.32) | 1.04E-11 | 36 (0 to 81) | 0.084 | 1.00 | Positive |
| 20p12.3 | rs961253 | 22 971 vs 25 270 (14*) | 14 | 1.11 (1.06 to 1.16) | 1.58E-05 | 60 (28 to 91) | 0.002 | 1.00 | 13 | 1.14 (1.06 to 1.22) | 7.10E-04 | 36 (0 to 96) | 0.098 | 1.00 | 14 | 1.14 (1.07 to 1.21) | 4.75E-05 | 57 (21 to 88) | 0.004 | 1.00 | Positive |
| 8q23.3 | rs16892766 | 8351 vs 8878 (6*) | 6 | 1.24 (1.15 to 1.34) | 1.67E-08 | 4 (0 to 92) | 0.393 | 0.99 | 6 | 1.21 (0.88 to 1.67) | 0.240 | 0 (0 to 85) | 0.747 | 0.22 | 6 | 1.27 (1.17 to 1.38) | 4.00E-09 | 3 (0 to 90) | 0.400 | 1.00 | Positive |
| 10p14 | rs10795668 | 16 763 vs 18 302 (16*) | 16 | 0.88 (0.83 to 0.94) | 4.35E-05 | 67 (34 to 89) | 6.94E-05 | 1.00 | 16 | 0.83 (0.77 to 0.89) | 4.77E-07 | 11 (0 to 70) | 0.332 | 1.00 | 16 | 0.85 (0.79 to 0.93) | 2.27E-04 | 68 (34 to 87) | 3.06E-05 | 1.00 | Positive |
| 11q23.1 | rs3802842 | 22 320 vs 22 965 (20*) | 20 | 1.15 (1.11 to 1.20) | 5.21E-12 | 43 (0 to 78) | 0.024 | 1.00 | 20 | 1.24 (1.13 to 1.35) | 3.62E-06 | 45 (5 to 86) | 0.017 | 1.00 | 20 | 1.19 (1.13 to 1.25) | 7.22E-12 | 33 (0 to 70) | 0.075 | 1.00 | Positive |
| BMP2 | rs355527 | 13 539 vs 14 375 (9) | 9 | 1.12 (1.08 to 1.17) | 1.65E-10 | 0 (0 to 0) | 0.977 | 0.99 | 9 | 1.18 (1.09 to 1.27) | 3.54E-05 | 0 (0 to 94) | 0.458 | 0.99 | 9 | 1.16 (1.10 to 1.21) | 2.43E-09 | 0 (0 to 9) | 0.966 | 1.00 | Positive |
| CDH1 | rs1862748 | 17 436 vs 18 418 (11) | 11 | 0.91 (0.88 to 0.94) | 1.98E-08 | 0 (0 to 63) | 0.703 | 0.98 | 11 | 0.83 (0.77 to 0.90) | 1.59E-06 | 2 (0 to 68) | 0.427 | 1.00 | 11 | 0.91 (0.87 to 0.95) | 6.31E-06 | 0 (0 to 70) | 0.511 | 0.99 | Positive |
| RHPN2 | rs7259371 | 15 762 vs 16 700 (9*) | 9 | 0.87 (0.82 to 0.93) | 1.65E-05 | 52 (0 to 90) | 0.034 | 1.00 | 9 | 0.85 (0.73 to 0.98) | 0.027 | 17 (0 to 86) | 0.295 | 0.71 | 9 | 0.86 (0.80 to 0.92) | 3.81E-06 | 42 (0 to 87) | 0.084 | 1.00 | Positive |
| TERT | rs2736100 | 16 176 vs 18 135 (8) | 8 | 1.07 (1.04 to 1.10) | 2.95E-05 | 0 (0 to 82) | 0.526 | 0.88 | 8 | 1.06 (1.00 to 1.13) | 0.069 | 15 (0 to 86) | 0.316 | 0.64 | 8 | 1.13 (1.08 to 1.20) | 2.03E-06 | 0 (0 to 64) | 0.788 | 1.00 | Positive |
| TGFB1 | rs1800469 | 4021 vs 6024 (10) | 10 | 0.89 (0.80 to 0.99) | 0.036 | 53(2t o 92) | 0.023 | 1.00 | 10 | 0.84 (0.74 to 0.94) | 0.003 | 0 (0 to 75) | 0.527 | 1.00 | 10 | 0.84 (0.71 to 1.00) | 0.051 | 58 (15 to 92) | 0.011 | 1.00 | Positive |
*Includes GWAS data from SOCCS.
GWASs, genome-wide association studies; SOCCS, Study of CRC in Scotland.