Table 2.
Summary of ‘less-credible associations’ from meta-analyses and credibility assessment
| Gene | Variant | Cases vs controls (number of samples) |
Allelic model | Recessive model: var/var vs wt/wt and wt/var | Dominant model: wt/var and var/var vs wt/wt | Classification | |||||||||||||||
| N | Effect size | Heterogeneity | N | Effect size | Heterogeneity | Power | N | Effect size | Heterogeneity | Power | |||||||||||
| OR (95% CI) | P value | I2 (95% CI) | P value | Power | OR (95% CI) | P value | I2 (95% CI) | P value | OR (95% CI) | P value | I2 (95% CI) | P value | |||||||||
| MTHFR | rs1801133 | 43 652 vs 60 883 (94*†) | 91 | 0.96 (0.93 to 0.99) | 8.79E-03 | 53 (59 to 85) | 3.61E-09 | 0.84 | 93 | 0.87 (0.81 to 0.93) | 7.36E-05 | 56 (63 to 86) | 6.79E-11 | 1.00 | 93 | 0.98 (0.94 to 1.02) | 0.249 | 48 (52 to 82) | 1.98E-07 | 0.36 | Less credible |
| miR | rs895819 | 1322 vs 1641 (4) | 4 | 1.18 (1.06 to 1.32) | 0.003 | 4 (0 to 95) | 0.373 | 0.09 | 4 | 1.50 (1.23 to 1.83) | 6.32E-05 | 1 (0 to 96) | 0.385 | 0.44 | 4 | 1.08 (0.93 to 1.26) | 0.302 | 0 (0 to 94) | 0.474 | 0.05 | Less credible |
| ADH1B | rs1229984 | 4449 vs 6995 (9) | 9 | 1.05 (0.94 to 1.18) | 0.401 | 57 (8 to 91) | 0.018 | 0.16 | 9 | 1.23 (1.02 to 1.48) | 0.028 | 0 (0 to 70) | 0.493 | 0.68 | 9 | 1.04 (0.90 to 1.20) | 0.595 | 60 (14 to 92) | 0.010 | 0.11 | Less credible |
| XRCC1 | rs25487 | 13 017 vs 18 166 (37) | 37 | 1.11 (1.03 to 1.19) | 0.008 | 71 (68 to 90) | 8.64E-12 | 0.74 | 36 | 1.17 (1.02 to 1.34) | 0.025 | 59 (39 to 80) | 3.14E-06 | 0.91 | 37 | 1.11 (1.01 to 1.21) | 0.023 | 63 (58 to 89) | 1.44E-07 | 0.88 | Less credible |
| HFE | rs1800562 | 6547 vs 34 156 (10‡) | 10 | 1.10 (1.01 to 1.20) | 0.035 | 0 (0 to 40) | 0.850 | 0.46 | 10 | 1.15 (0.69 to 1.92) | 0.582 | 24 (0 to 84) | 0.240 | 0.12 | 10 | 1.10 (1.01 to 1.21) | 0.037 | 0 (0 to 25) | 0.937 | 0.68 | Less credible |
| MTHFR | rs1801131 | 23 523 vs 35 193 (57*) | 57 | 0.98 (0.95 to 1.01) | 0.258 | 22 (0 to 57) | 0.075 | 0.19 | 57 | 0.91 (0.84 to 0.98) | 0.010 | 23 (0 to 62) | 0.064 | 0.94 | 57 | 1.00 (0.96 to 1.04) | 0.970 | 10 (0 to 48) | 0.270 | 0.50 | Less credible |
| CYP2C9 | rs1799853 | 9588 vs 11 428 (12) | 12 | 0.95 (0.90 to 1.01) | 0.086 | 0 (0 to 73) | 0.530 | 0.26 | 12 | 1.16 (0.96 to 1.40) | 0.127 | 0 (0 to 73) | 0.667 | 0.39 | 12 | 0.93 (0.87 to 0.99) | 0.015 | 0 (0 to 72) | 0.452 | 0.65 | Less credible |
| CRP | rs1800947 | 2853 vs 3381 (3) | 2 | 1.03 (0.88 to 1.20) | 0.745 | 0 (0 to 100) | 0.334 | 0.10 | 2 | 3.95 (1.35 to 11.56) | 0.012 | 7 (0 to 99) | 0.301 | 1.00 | 3 | 0.96 (0.82 to 1.12) | 0.604 | 0 (0 to 81) | 0.911 | 0.08 | Less credible |
| CRP | rs1205 | 3037 vs 9333 (4) | 4 | 1.07 (1.00 to 1.15) | 0.065 | 0 (0 to 95) | 0.479 | 0.34 | 4 | 1.18 (1.02 to 1.37) | 0.027 | 0 (0 to 94) | 0.431 | 0.73 | 4 | 1.05 (0.96 to 1.16) | 0.288 | 0 (0 to 90) | 0.669 | 0.21 | Less credible |
| EGF | rs4444903 | 899 vs 976 (5) | 5 | 0.83 (0.64 to 1.07) | 0.143 | 70 (18 to 97) | 0.010 | 0.52 | 5 | 0.91 (0.63 to 1.31) | 0.601 | 50 (0 to 92) | 0.093 | 0.13 | 5 | 0.65 (0.44 to 0.96) | 0.030 | 67 (12 to 97) | 0.016 | 0.99 | Less credible |
| ESR2 | rs928554 | 2574 vs 2977 (3) | 3 | 1.09 (1.01 to 1.18) | 0.025 | 0 (0 to 89) | 0.743 | 0.35 | 3 | 1.12 (0.97 to 1.29) | 0.118 | 0 (0 to 93) | 0.590 | 0.36 | 3 | 1.13 (1.01 to 1.26) | 0.041 | 0 (0 to 89) | 0.876 | 0.57 | Less credible |
| HPGD | rs8752 | 3968 vs 4830 (3‡) | 3 | 1.05 (0.92 to 1.21) | 0.467 | 80 (23 to 99) | 0.007 | 0.20 | 3 | 1.12 (1.00 to 1.26) | 0.047 | 6 (0 to 97) | 0.345 | 0.53 | 3 | 1.03 (0.83 to 1.29) | 0.786 | 83 (34 to 99) | 0.003 | 0.10 | Less credible |
| LIPC | rs6083 | 7667 vs 7980 (4‡) | 4 | 0.96 (0.90 to 1.02) | 0.172 | 41 (0 to 95) | 0.167 | 0.23 | 4 | 0.89 (0.80 to 0.99) | 0.033 | 22 (0 to 94) | 0.278 | 0.68 | 4 | 0.98 (0.91 to 1.05) | 0.519 | 11 (0 to 92) | 0.340 | 0.10 | Less credible |
| miR | rs2292832 | 2355 vs 2571 (5‡) | 5 | 0.94 (0.86 to 1.02) | 0.152 | 0 (0 to 82) | 0.650 | 0.17 | 5 | 1.06 (0.89 to 1.27) | 0.522 | 0 (0 to 73) | 0.789 | 0.10 | 5 | 0.87 (0.78 to 0.98) | 0.021 | 0 (0 to 88) | 0.704 | 0.68 | Less credible |
| MSH2 | rs4608577 | 4308 vs 4011 (3‡) | 3 | 0.94 (0.86 to 1.02) | 0.112 | 0 (0 to 91) | 0.795 | 0.19 | 3 | 0.72 (0.56 to 0.92) | 0.008 | 0 (0 to 95) | 0.648 | 0.68 | 3 | 0.96 (0.88 to 1.05) | 0.406 | 0 (0 to 62) | 0.945 | 0.14 | Less credible |
| MSH3 | rs184967 | 8151 vs 10 103 (4‡) | 4 | 1.08 (1.00 to 1.16) | 0.049 | 35 (0 to 98) | 0.204 | 0.47 | 4 | 1.23 (1.02 to 1.49) | 0.031 | 0 (0 to 91) | 0.702 | 0.59 | 4 | 1.07 (0.99 to 1.16) | 0.098 | 28 (0 to 98) | 0.242 | 0.54 | Less credible |
| MSH3 | rs26779 | 6050 vs 8024 (6‡) | 6 | 1.07 (1.02 to 1.14) | 0.013 | 11 (0 to 92) | 0.343 | 0.46 | 6 | 1.13 (0.98 to 1.31) | 0.085 | 36 (0 to 93) | 0.166 | 0.59 | 6 | 1.08 (1.01 to 1.15) | 0.030 | 0 (0 to 85) | 0.682 | 0.62 | Less credible |
| MTHFD1 | rs1950902 | 9059 vs 11 358 (7‡) | 7 | 0.94 (0.89 to 0.99) | 0.026 | 3 (0 to 82) | 0.400 | 0.39 | 7 | 1.01 (0.87 to 1.18) | 0.878 | 0 (0 to 91) | 0.767 | 0.05 | 7 | 0.92 (0.86 to 0.98) | 0.015 | 15 (0 to 90) | 0.313 | 0.79 | Less credible |
| PARP1 | rs1136410 | 7002 vs 8328 (7‡) | 7 | 1.05 (0.95 to 1.17) | 0.300 | 52 (0 to 98) | 0.052 | 0.24 | 7 | 1.23 (1.05 to 1.44) | 0.012 | 0 (0 to 92) | 0.475 | 0.78 | 7 | 1.03 (0.93 to 1.15) | 0.529 | 36 (0 to 94) | 0.153 | 0.14 | Less credible |
| PGR | rs1042838 | 5232 vs 5733 (4‡) | 4 | 1.08 (1.01 to 1.16) | 0.034 | 0 (0 to 95) | 0.507 | 0.32 | 4 | 0.97 (0.77 to 1.23) | 0.819 | 0 (0 to 85) | 0.880 | 0.06 | 4 | 1.11 (1.02 to 1.21) | 0.012 | 0 (0 to 96) | 0.450 | 0.71 | Less credible |
| rs4951039 | 13 791 vs 14 288 (7‡) | 7 | 0.91 (0.81 to 1.02) | 0.106 | 81 (49 to 95) | 1.48E-05 | 0.79 | 7 | 0.78 (0.66 to 0.93) | 0.005 | 0 (0 to 68) | 0.620 | 0.82 | 7 | 0.91 (0.80 to 1.04) | 0.163 | 82 (51 to 96) | 9.30E-06 | 0.94 | Less credible | |
| SCD | rs7849 | 2011 vs 2580 (3) | 3 | 0.85 (0.73 to 0.98) | 0.025 | 29 (0 to 98) | 0.247 | 0.53 | 3 | 0.64 (0.40 to 1.02) | 0.058 | 41 (0 to 99) | 0.185 | 0.68 | 3 | 0.85 (0.71 to 1.02) | 0.084 | 33 (0 to 99) | 0.225 | 0.72 | Less credible |
| XPC | rs2228000 | 2677 vs 4253 (6) | 6 | 0.99 (0.71 to 1.36) | 0.929 | 94 (82 to 99) | 1.35E-16 | 0.05 | 6 | 0.95 (0.49 to 1.81) | 0.866 | 91 (71 to 99) | 2.18E-10 | 0.09 | 6 | 0.58 (0.41 to 0.82) | 0.002 | 92 (83 to 99) | 1.49E-11 | 1.00 | Less credible |
| VEGF | rs699947 | 4497 vs 5334 (10‡) | 10 | 1.09 (1.00 to 1.19) | 0.056 | 46 (0 to 91) | 0.053 | 0.56 | 10 | 1.14 (1.01 to 1.29) | 0.029 | 14 (0 to 89) | 0.317 | 0.74 | 10 | 1.09 (0.95 to 1.24) | 0.219 | 47 (0 to 87) | 0.047 | 0.50 | Less credible |
| IGF1 | rs35767 | 2792 vs 4988 (3) | 3 | 0.95 (0.80 to 1.14) | 0.599 | 59 (0 to 99) | 0.087 | 0.15 | 3 | 0.75 (0.62 to 0.91) | 0.003 | 0 (0 to 97) | 0.567 | 0.79 | 3 | 0.98 (0.79 to 1.21) | 0.826 | 60 (0 to 99) | 0.081 | 0.07 | Less credible |
| NAT2 | rs1799929 | 1861 vs 1952 (5*) | 5 | 0.84 (0.74 to 0.95) | 0.004 | 20 (0 to 94) | 0.289 | 0.53 | 5 | 0.68 (0.47 to 0.99) | 0.044 | 68 (14 to 98) | 0.015 | 0.81 | 5 | 0.85 (0.74 to 0.97) | 0.016 | 0 (0 to 85) | 0.872 | 0.61 | Less credible |
| NAT2 | rs1799930 | 6446 vs 7193 (8*) | 8 | 1.07 (0.99 to 1.16) | 0.099 | 44 (0 to 96) | 0.082 | 0.25 | 8 | 0.99 (0.88 to 1.12) | 0.897 | 0 (0 to 64) | 0.812 | 0.08 | 8 | 1.13 (1.00 to 1.27) | 0.043 | 51 (0 to 97) | 0.045 | 0.70 | Less credible |
| ABCB1 (MDR1) | rs9282564 | 9536 vs 9145 (6‡) | 6 | 1.07 (1.00 to 1.14) | 0.053 | 0 (0 to 77) | 0.561 | 0.29 | 6 | 0.88 (0.65 to 1.19) | 0.424 | 18 (0 to 86) | 0.299 | 0.14 | 6 | 1.09 (1.01 to 1.17) | 0.018 | 0 (0 to 70) | 0.729 | 0.65 | Less credible |
| ABCB1 (MDR1) | rs1045642 | 7537 vs 8396 (16) | 16 | 0.94 (0.88 to 1.01) | 0.108 | 46 (1 to 88) | 0.024 | 0.50 | 16 | 0.89 (0.81 to 0.97) | 0.012 | 18 (0 to 78) | 0.248 | 0.87 | 16 | 0.97 (0.85 to 1.10) | 0.608 | 57 (32 to 91) | 0.003 | 0.14 | Less credible |
| ABCB1 (MDR1) | rs1202168 | 7000 vs 6485 (5) | 5 | 1.06 (0.99 to 1.14) | 0.071 | 45 (0 to 93) | 0.124 | 0.39 | 5 | 1.04 (0.95 to 1.14) | 0.350 | 0 (0 to 81) | 0.699 | 0.14 | 5 | 1.12 (1.00 to 1.24) | 0.042 | 52 (0 to 93) | 0.080 | 0.88 | Less credible |
| ADIPOR1 | rs1342387 | 2472 vs 2848 (5‡) | 5 | 0.87 (0.78 to 0.98) | 0.018 | 48 (0 to 95) | 0.105 | 0.71 | 5 | 0.84 (0.73 to 0.96) | 0.012 | 0 (0 to 62) | 0.900 | 0.68 | 5 | 0.85 (0.69 to 1.03) | 0.098 | 63 (0 to 96) | 0.029 | 0.79 | Less credible |
| AXIN2 | rs2240308 | 4723 vs 4932 (4‡) | 4 | 1.06 (1.00 to 1.12) | 0.044 | 0 (0 to 92) | 0.397 | 0.30 | 4 | 1.07 (0.96 to 1.19) | 0.219 | 17 (0 to 95) | 0.306 | 0.29 | 4 | 1.10 (1.01 to 1.21) | 0.037 | 0 (0 to 76) | 0.758 | 0.54 | Less credible |
| MMP1 | rs1799750 | 1660 vs 2024 (10) | 9 | 0.78 (0.66 to 0.93) | 0.005 | 59 (8 to 88) | 0.012 | 0.95 | 9 | 0.78 (0.61 to 0.99) | 0.041 | 21 (0 to 68) | 0.254 | 0.75 | 10 | 0.70 (0.56 to 0.88) | 0.002 | 57 (9 to 88) | 0.013 | 1.00 | Less credible |
| CYP1A1 | rs1048943 | 9661 vs 11 774 (19*) | 19 | 1.28 (1.07 to 1.52) | 0.006 | 84 (83 to 96) | 1.15E-15 | 1.00 | 18 | 1.26 (1.04 to 1.52) | 0.016 | 0 (0 to 55) | 0.456 | 0.72 | 19 | 1.36 (1.08 to 1.72) | 0.009 | 88 (93 to 98) | 2.16E-23 | 1.00 | Less credible |
| GSTT1 | Null variant | 19 133 vs 27 821 (56) | 7 | 0.91 (0.70 to 1.20) | 0.508 | 71 (21 to 99) | 0.015 | 0.49 | 53 | 1.17 (1.07 to 1.28) | 0.001 | 70 (71 to 90) | 1.62E-15 | 1.00 | 6 | 1.00 (0.73 to 1.37) | 0.979 | 53 (0 to 98) | 0.059 | 0.05 | Less credible |
| VDR | rs1544410 | 14 789 vs 15 922 (16‡) | 16 | 0.83 (0.72 to 0.96) | 0.011 | 93 (91 to 95) | 5.59E-40 | 1.00 | 16 | 0.81 (0.67 to 0.98) | 0.033 | 85 (77 to 89) | 1.08E-14 | 1.00 | 16 | 0.82 (0.69 to 0.96) | 0.015 | 88 (83 to 91) | 2.62E-20 | 1.00 | Less credible |
| 8q24 | rs6983267 | 51 730 vs 53 589 (34‡) | 34 | 1.11 (1.06 to 1.17) | 1.75E-05 | 85 (77 to 93) | 1.93E-28 | 1.00 | 34 | 1.16 (1.08 to 1.25) | 4.92E-05 | 79 (66 to 89) | 2.80E-18 | 1.00 | 34 | 1.16 (1.08 to 1.24) | 2.98E-05 | 80 (69 to 92) | 8.68E-19 | 1.00 | Less credible |
| RAD18 | rs373572 | 6560 vs 6906 (5‡) | 5 | 1.15 (1.01 to 1.30) | 0.031 | 75 (33 to 98) | 0.003 | 0.96 | 5 | 1.23 (1.01 to 1.49) | 0.041 | 54 (0 to 95) | 0.067 | 0.93 | 5 | 1.15 (0.98 to 1.36) | 0.080 | 73 (21 to 98) | 0.005 | 0.98 | Less credible |
| NQ01 | rs1800566 | 11 183 vs 12 525 (16‡) | 16 | 1.17 (1.05 to 1.30) | 0.006 | 80 (66 to 94) | 1.17E-09 | 1.00 | 16 | 1.21 (0.99 to 1.48) | 0.060 | 55 (17 to 87) | 0.004 | 0.91 | 16 | 1.20 (1.06 to 1.37) | 0.006 | 78 (64 to 94) | 8.77E-09 | 1.00 | Less credible |
| PTGS2/COX2 | rs20417 | 7785 vs 11 371 (18) | 17 | 1.10 (1.00 to 1.2) | 0.035 | 37 (0 to 83) | 0.062 | 0.57 | 17 | 1.24 (1.04 to 1.47) | 0.016 | 0 (0 to 46) | 0.928 | 0.64 | 18 | 1.12 (1.00 to 1.26) | 0.050 | 51 (14 to 87) | 0.019 | 0.90 | Less credible |
| NOD2 | rs2066844 | 3297 vs 3088 (9) | 9 | 1.38 (1.04 to 1.84) | 0.026 | 39 (0 to 91) | 0.109 | 0.66 | 9 | 1.97 (0.55 to 7.04) | 0.299 | 0 (0 to 83) | 0.689 | 0.17 | 9 | 1.35 (1.02 to 1.78) | 0.033 | 33 (0 to 90) | 0.155 | 0.86 | Less credible |
| CCND1 | rs17852153 | 6500 vs 8885 (20) | 20 | 1.10 (1.02 to 1.19) | 0.019 | 58 (45 to 92) | 0.001 | 0.83 | 20 | 1.11 (0.97 to 1.28) | 0.128 | 63 (54 to 94) | 7.69E-05 | 0.82 | 20 | 1.15 (1.05 to 1.26) | 0.003 | 18 (0 to 76) | 0.226 | 0.94 | Less credible |
| GSTM1 | Null variant | 28 240 vs 38 880 (74) | 13 | 1.12 (0.89 to 1.40) | 0.335 | 70 (22 to 98) | 0.005 | 1.00 | 6 | 1.18 (0.90 to 1.55) | 0.234 | 67 (0 to 98) | 0.028 | 1.00 | 74 | 1.10 (1.05 to 1.16) | 0.001 | 47 (34 to 75) | 6.63E-06 | 1.00 | Less credible |
| 9p24 | rs719725 | 13 513 vs 14 999 (14) | 14 | 1.07 (1.02 to 1.11) | 0.002 | 24 (0 to 79) | 0.190 | 0.79 | 14 | 1.09 (1.02 to 1.15) | 0.006 | 29 (0 to 75) | 0.148 | 0.94 | 14 | 1.09 (1.02 to 1.17) | 0.008 | 0 (0 to 66) | 0.521 | 0.72 | Less credible |
| ERCC5 | rs17655 | 9653 vs 11 367 (14) | 13 | 1.07 (1.02 to 1.12) | 0.003 | 0 (0 to 73) | 0.626 | 0.60 | 13 | 0.98 (0.89 to 1.08) | 0.688 | 0 (0 to 77) | 0.538 | 0.07 | 14 | 1.14 (1.04 to 1.24) | 0.004 | 44 (0 to 85) | 0.038 | 1.00 | Less credible |
| GH1 | rs2665802 | 3275 vs 3848 (7) | 7 | 0.89 (0.80 to 0.99) | 0.025 | 49 (0 to 97) | 0.069 | 0.68 | 7 | 0.83 (0.71 to 0.98) | 0.028 | 37 (0 to 95) | 0.144 | 0.87 | 7 | 0.89 (0.78 to 1.02) | 0.103 | 36 (0 to 96) | 0.157 | 0.62 | Less credible |
| TP73 | G4C14 | 858 vs 1173 (4) | 4 | 1.21 (1.04 to 1.40) | 0.013 | 4 (0 to 92) | 0.371 | 0.46 | 4 | 1.75 (1.23 to 2.48) | 0.002 | 0 (0 to 94) | 0.513 | 0.91 | 4 | 1.10 (0.83 to 1.45) | 0.501 | 55 (0 to 96) | 0.083 | 0.18 | Less credible |
| TGFB1 | rs4803455 | 3747 vs 4513 (3‡) | 3 | 1.11 (1.04 to 1.18) | 0.001 | 0 (0 to 71) | 0.903 | 0.66 | 3 | 1.12 (1.01 to 1.24) | 0.027 | 0 (0 to 80) | 0.845 | 0.59 | 3 | 1.18 (1.06 to 1.30) | 0.001 | 0 (0 to 85) | 0.879 | 0.90 | Less credible |
| APC | rs1801155 | 2389 vs 4223 (5) | 5 | 1.60 (1.21 to 2.11) | 0.001 | 27 (0 to 94) | 0.244 | 0.85 | na | na | na | na | na | na | 5 | 1.62 (1.21 to 2.16) | 0.001 | 28 (0 to 94) | 0.235 | 0.99 | Less credible |
| MLH1 | rs63750447 | 937 vs 812 (4) | 3 | 2.14 (1.12 to 4.10) | 0.022 | 39 (0 to 99) | 0.194 | 0.75 | na | na | na | na | na | na | 3 | 2.17 (1.14 to 4.14) | 0.019 | 36 (0 to 98) | 0.208 | 0.96 | Less credible |
| VDR | rs11568820 | 4001 vs 4682 (5*) | 4 | 1.14 (1.05 to 1.23) | 0.001 | 0 (0 to 92) | 0.648 | 0.71 | 4 | 1.37 (1.02 to 1.85) | 0.039 | 35 (0 to 97) | 0.203 | 0.90 | 5 | 1.14 (1.04 to 1.24) | 0.004 | 0 (0 to 0) | 0.989 | 0.85 | Less credible |
| ABCB1 (MDR1) | rs1128503 | 246 vs 399 (3) | 3 | 0.70 (0.51 to 0.96) | 0.027 | 45 (0 to 98) | 0.164 | 0.59 | 3 | 0.77 (0.37 to 1.59) | 0.483 | 71 (0 to 99) | 0.031 | 0.31 | 3 | 0.52 (0.35 to 0.76) | 0.001 | 0 (0 to 96) | 0.617 | 0.93 | Less credible |
| ADIPOQ | rs2241766 | 1517 vs 1909 (5) | 5 | 1.17 (1.01 to 1.35) | 0.033 | 29 (0 to 97) | 0.231 | 0.50 | 5 | 1.04 (0.74 to 1.45) | 0.830 | 14 (0 to 98) | 0.325 | 0.06 | 5 | 1.26 (1.09 to 1.47) | 0.002 | 8 (0 to 96) | 0.364 | 0.92 | Less credible |
| CHEK2 | rs1787996 | 1687 vs 3370 (3) | 3 | 1.47 (1.12 to 1.92) | 0.006 | 0 (0 to 98) | 0.499 | 0.53 | na | na | na | na | na | na | 3 | 1.48 (1.13 to 1.95) | 0.005 | 0 (0 to 98) | 0.496 | 0.81 | Less credible |
| CHEK2 | 1100delC | 2417 vs 3615 (4) | 4 | 1.66 (1.01 to 2.73) | 0.048 | 0 (0 to 83) | 0.835 | 0.60 | na | na | na | na | na | na | 4 | 1.66 (1.01 to 2.75) | 0.047 | 0 (0 to 83) | 0.835 | 0.86 | Less credible |
| TP53 | rs1042522 | 10591 vs 12 673 (30) | 30 | 1.11 (0.99 to 1.24) | 0.077 | 85 (84 to 95) | 4.42E-26 | 0.73 | 30 | 1.21 (1.02 to 1.44) | 0.026 | 70 (55 to 88) | 2.77E-09 | 0.98 | 30 | 1.11 (0.96 to 1.28) | 0.163 | 82 (84 to 05) | 7.58E-20 | 0.64 | Less credible |
| TP53 | rs17878362 | 1812 vs 2319 (6) | 6 | 0.98 (0.76 to 1.26) | 0.859 | 70 (23 to 96) | 0.005 | 0.06 | 6 | 1.28 (0.81 to 2.03) | 0.282 | 0 (0 to 79) | 0.638 | 0.22 | 6 | 0.95 (0.71 to 1.27) | 0.734 | 71 (25 to 96) | 0.004 | 0.40 | Less credible |
| KRAS | rs712 | 1982 vs 2194 (3) | 3 | 1.22 (0.86 to 1.72) | 0.270 | 90 (55 to 100) | 6.87E-05 | 0.19 | 3 | 1.72 (0.73 to 4.06) | 0.215 | 87(44 to 100) | 3.74E-04 | 0.16 | 3 | 1.17 (0.84 to 1.65) | 0.350 | 83 (32 to 99) | 0.003 | 0.28 | Less credible |
| ARLTS1 | rs3803185 | 2281 vs 3196 (5†) | 5 | 1.09 (1.01 to 1.18) | 0.026 | 0 (0 to 76) | 0.803 | 0.35 | 5 | 1.08 (0.90 to 1.29) | 0.432 | 43 (0 to 93) | 0.133 | 0.21 | 5 | 1.18 (0.95 to 1.46) | 0.131 | 62 (0 to 96) | 0.032 | 0.77 | Less credible |
| 1q32.1 | rs4951291 | 15 835 vs 16 724 (9‡) | 9 | 0.91 (0.84 to 0.99) | 0.021 | 68 (22 to 88) | 0.002 | 0.85 | 9 | 0.74 (0.62 to 0.87) | 2.72E-04 | 0 (0 to 69) | 0.616 | 0.95 | 9 | 0.92 (0.83 to 1.01) | 0.077 | 72 (30 to 90) | 4.33E-04 | 0.91 | Less credible |
| PPAR-gamma | rs9858822 | 2152 vs 2630 (5) | 4 | 1.40 (1.19 to 1.65) | 4.69E-05 | 0 (0 to 98) | 0.697 | 0.96 | 2 | 1.69 (1.19 to 2.39) | 0.003 | 0 (0 to 98) | 0.801 | 0.54 | 4 | 1.47 (1.19 to 1.83) | 4.55E-04 | 0 (0 to 98) | 0.618 | 1.00 | Less credible |
| DNMT3B | rs1569686 | 1224 vs 1381 (5) | 4 | 0.57 (0.47 to 0.68) | 1.81E-09 | 0 (0 to 0) | 0.992 | 1.00 | 4 | 0.93 (0.54 to 1.58) | 0.775 | 0 (0 to 97) | 0.414 | 0.06 | 5 | 0.46 (0.36 to 0.59) | 2.40E-09 | 30 (0 to 95) | 0.223 | 1.00 | Less credible |
| NOD2 | rs2066847 | 4573 vs 3733 (10) | 10 | 1.39 (1.16 to 1.66) | 3.21E-04 | 0 (0 to 71) | 0.547 | 0.78 | 10 | 2.36 (0.69 to 8.13) | 0.173 | 0 (0 to 76) | 0.720 | 0.31 | 10 | 1.38 (1.14 to 1.66) | 0.001 | 0 (0 to 74) | 0.488 | 0.96 | Less credible |
*Includes GWAS data from Ontario.
†Tomlinson 2008 was based on 10 samples.
‡Includes GWAS data from SOCCS.
GWASs, genome-wide association studies; SOCCS, Study of CRC in Scotland.