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. Author manuscript; available in PMC: 2020 Aug 3.
Published in final edited form as: Cancer Immunol Res. 2019 Oct 15;7(12):2013–2024. doi: 10.1158/2326-6066.CIR-19-0121

Figure 2.

Figure 2.

Comparisons of antibody-dependent cellular cytotoxicity and surface plasmon resonance analysis of binding to mouse Fcγ receptors. A, Antibody-dependent cellular cytotoxicity of GD2-BsAb and its Fc mutants against GD2+ IMR-32 cells. Effector to target ratio was 20:1. B, Antibody-dependent cellular cytotoxicity of HER2-BsAb and its Fc mutants against HER2+ AU565 Cells. Effector to target ratio was 20:1. Binding kinetics of BsAb and Fc mutants to mouse FcγRI (C, GD2-bind series, and D, HER2-binding series) and FcγRIV (E, GD2-bind series, and F, HER2-binding series). Protein binding to the SPR chip surface was measured in resonance units (RU). The results shown are representative results from at least three independent repeats.