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. Author manuscript; available in PMC: 2020 Sep 11.
Published in final edited form as: Nature. 2020 Mar 11;580(7802):278–282. doi: 10.1038/s41586-020-2110-6

Figure 1 |. Human ID complex bound to ICL DNA.

Figure 1 |

a, Overall structure with FANCI colored cyan, FANCD2 salmon, and ICL DNA yellow. The mono-ubiquitination sites are shown as sticks (labeled). The helical axes of the DNA duplexes are shown as gray lines. Inset shows schematic of the ICL DNA, with triazole-linked deoxycytidine residues in red (not built in structure). b, View looking down the left side of the horizontal axis of a. c, Cryo-EM density without temperature-factor sharpening. Orientation similar to a. DNA model is red, and its density yellow. d, Linear representation marking domain boundaries. Darker hues are disordered C-terminal segments that become ordered on ubiquitination; dashed lines disordered in both.