(A) MWM test for SS and vehicle-treated APP/PS1 and WT mice. The mean escape latency was given for different test days. (B) The mean percent time in probe trial of MWM on day 7. TQ: Target quadrant; AL: Adjacent left; AR: Adjacent right; OP: Opposite. (C) Representative mice search paths from different groups. (D and E) The latency to target quadrant (D) and the frequency to pass the target position (E) in probe trial are shown. (F and G) The swimming velocity (F) and distance (G) in probe trial are shown. (H and I) Novel object recognition analysis. Preference scores of training phase (H) and Recognition Index of testing phase (I) during a 10-min testing phase are shown, respectively. nā = ā8ā11 for each group. *P<0.05, **P<0.01, ***P<0.001, #P<0.05, ##P<0.01, ###P<0.001.