Table 5.

Plasma toxicokinetic parameters of trans-resveratrol-3-sulfate (R3S) and resveratrol-3-O-β-D-glucuronide (R3G) in male and female B6C3F1/N mice following gavage administration of trans-resveratrol (RES)

Parameter	625 mg/kg		1250 mg/kg		2500 mg/kg
	Male	Female	Male	Female	Male	Female
R3S
Cmax_predicted (ng/mL)	9660±2560	9160±2230	5250±1570	9560±3190	6470±1020	9770±1860
Cmax_predicted/Dose (ng/mL)/(mg/kg)	15.5±4.1	14.7±3.6	4.20±1.26	7.65±2.55	2.59±0.41	3.91±0.74
Tmax_predicted (min)	101±30	55.6±22.8	108±40	123±48	156±28	150±31
k01 half-life (min)	0.114	0.0497	0.0184	0.0158	0.00652	0.00717
k10 half-life (min)	95.7±51.8	177±48	182±89	200±128	110±1510	112±335
Cl_F (mL/min/kg)	226±65	215±45	601±157	296±86	913±139	625±113
V_F (mL/kg)	31200±23200	54900±18600	158000±91000	85300±58700	144000±2000000	101000±310000
AUClast (min*ng/mL)	1410000	2930000	1810000	3160000	2630000	4020000
AUC∞_predicted (min*ng/mL)	2770000±790000	2910000±610000	2080000±540000	4220000±1220000	2740000±420000	4000000±720000
AUC∞/Dose (min*ng/mL)/(mg/kg)	4430±1260	4660±980	1660±430	3390±980	1100±170	1600±290
R3G
Cmax_predicted (ng/mL)	24000±4700	32100±7800	38100±10700	30000±6500	56300±14400	76600±18600
Cmax_predicted /Dose (ng/mL)/(mg/kg)	38.4±7.5	51.4±12.5	30.5±8.6	24.0±5.2	22.5±5.8	30.6±7.4
Tmax_predicted (min)	28.3±17.1	49.7±22.5	105±37	60.6±23.3	160±42	180±43
k01 half-life (min)	0.172	0.0667	0.0251	0.0637	0.013	0.00998
k10 half-life (min)	499±255	248±86	302±170	472±263	290±203	258±205
Cl_F (mL/min/kg)	34.7±13.6	47.3±11.0	59.2±17.5	56.0±22.0	72.5±20.7	54.2±14.3
V_F (mL/kg)	25000±5500	16900±5300	25800±11600	38100±10400	30300±17000	20100±13500
AUClast (min*ng/mL)	11100000	12900000	16500000	14500000	33200000	31200000
AUC∞_predicted (min*ng/mL)	18000000±7000000	13200000±3100000	21100000±6200000	22300000±8800000	34500000±9900000	46200000±12200000
AUC∞/Dose (min*ng/mL)/(mg/kg)	28800±11200	21100±5000	16900±5000	17800±7000	13800±4000	18500±4900