Table 7.
Comparison of Dose-Normalized Cmax and AUC of trans-resveratrol (RES), trans-resveratrol-3-sulfate (R3S) and resveratrol-3-O-β-D-glucuronide (R3G)Following Single Dose Gavage Administration in Rats and Mice
| Rodents | Dose (mg/kg) | RES | R3S | R3G | |||
|---|---|---|---|---|---|---|---|
| Cmax/Dose (ng/mL)/(mg/kg) | AUC∞/Dose (min*ng/mL)/(mg/kg) | Cmax/Dose (ng/mL)/(mg/kg) | AUC∞/Dose (ng/mL)/(mg/kg) | Cmax/Dose (ng/mL)/(mg/kg) | AUC∞/Dose (ng/mL)/(mg/kg) | ||
| HSD Ratsa | 312.5 | 2.89 | 26.2 | 15.6 | 138 | 96.3 | 1080 |
| 625 | 1.87 | 19.8 | 9.66 | 130 | 50.7 | 605 | |
| 1250 | 1.16 | 41.0 | 12.5 | 247 | 51.4 | 1600 | |
| B6C3F1/Na | 625 | 2.11 | 10.2 | 15.5 | 73.8 | 38.4 | 480 |
| 1250 | 1.48 | 8.10 | 4.20 | 27.7 | 30.5 | 282 | |
| 2500 | 0.756 | 9.40 | 2.59 | 18.3 | 22.5 | 230 | |
| SD Ratsb | 50 | 29.98 | 32.4 | NA | NA | 850.9 | 2626.2 |
| CD Ratsc | 50 | 1.5 | 27 | 4.4 | 252 | 4.6 | 232.0 |
| 150 | 5.6 | 17.2 | 58.3 | 306.7 | 24.9 | 151.3 | |
| SD Ratsd | 100 | NA | 53.3 | NA | NA | NA | NA |
Current study, AUC values were converted from min*ng/mL to hr*mg/mL for comparison.
Marier et al. 2002 (Marier, Vachon et al. 2002), Cmax values of 6.57 and 105.2 μmol/L were converted to ng/mL and AUC∞ values of 7.1 and 324.7 hr*μmol/L were converted to hr*ng/mL using MW of 228.25 and 404.4 g/mol for RES and R3G respectively.
Kapetanovic 2011(Kapetanovic, Muzzio et al. 2011), Cmaxvalues at 50 mg/kg were 76.7, 2020, and 2290 ng/mL and at 150 mg/kg were 847, 8710, and 3740 ng/mL for RES, R3S and R3G, respectively. AUC∞ values at 50 mg/kg were 1350, 12600, and 11600 ng/mL and at 150 mg/kg were 2580, 46000, and 22700 hr*ng/mL for RES, R3S and R3G, respectively.
Liang et al 2013(Liang, Liu et al. 2013), AUC∞ value of 320 min*mg/L was converted to 5333.3 hr*ng/L.
NA Not applicable