. Author manuscript; available in PMC: 2020 Aug 3.

Published in final edited form as: Toxicol Appl Pharmacol. 2020 Mar 20;394:114962. doi: 10.1016/j.taap.2020.114962

Table 8.

Comparison Between Current Study and Humans

Current Study Doses mg/kg (mg/m²)	Human Doses mg/kg (mg/m²) ^c	Exposure multiple (rat/human)
		mg/kg	mg/m²	C_max	AUC
		mg/kg	mg/m²	RES	RES
HSD Rats
312.5 (1875)^a	41.6 (1539.2)	7.5	1.2	3.4	10.4
625 (3750)^a	83.3 (3082.1)	7.5	1.2	2.2	9.4
B6C3F1/N mice
625 (1875) ^b	41.6 (1539.2)	15.0	1.2	4.9	8.1
1250 (3750)^b	83.3 (3082.1)	15.0	1.2	3.4	7.7

Current study male HSD rats, Cmax (ng/mL) and AUC (ng*h/mL) values are presented in Table 2.

Current study male B6C3F1/N mice, Cmax (ng/mL) and AUC (ng*h/mL) values are presented in Table 4.

Boocock et al 2007 (Boocock, Faust et al. 2007), following C_max (ng/mL) and AUC_∞ (ng*h/mL) values reported following 2.5 and 5.0 g of RES administration were used, Cmax (2.5 and 5.0 g, respectively) 268.0 and 538.8 for RES; AUC (2.5 and 5.0 g, respectively) 786.5 and 1319 for RES, mg/kg doses were calculated based on 60 kg human body weight.