TABLE 1.

Comparative analysis of human and human herpesviruses highlights integration of miR-mediated post-transcriptional regulation by most herpesviruses. Computed genomic landscape occupancy (per kb per miR) and protein coding gene to miR ratio of human and miR-encoding HHV

		Genome Size (Transcripts Encoded)	Precursor miR Expressed (Mature miR)	Ratio of Genome size/ miR	Ratio of Gene/miR
Human		3 billion base (~73 000)	1917 (2300)	1.5 Mb/miR	~38
Human Herpesvirus	Common Clinical Manifestations
HSV-1 (α)	gingivostomatitis, herpetic keratitis, dermal whitlows; encephalitis in neonates	152 kb (90)	18 (27)	8.4 kb/miR	5
HSV-2 (α)	Genital herpes	155 kb (74)	18 (24)	8.6 kb/miR	4
HCMV (β)	mononucleosis syndrome, systemic diseases observed in congenital infection or immunocompromised individuals	235 kb (213)	15 (26)	15 kb/miR	14
HHV-6B (β)	exanthem subitum	161 kb (115)	4 (8)	40 kb/miR	28
EBV(γ)	Infectious mononucleosis, oral hairy leukoplakia, lymphoproliferative syndrome in immunocompromised hosts	172 kb (85)	25 (44)	6.8 kb/miR	3.4
KSHV (γ)	Kaposi’s sarcoma, Primary effusion lymphomas and Castleman’s disease	140 kb (87)	13 (25)	10.7 kb/miR	6.6