A. At 24 hours, cisplatin, phenanthriplatin and pyriplatin treatment caused elevated ROS production compared to the control. B. At 48 hours, ROS levels are not significantly different than control for all three platinum compounds. Labeling: Positive control (+), negative control (−), cisplatin (Cis), phenanthriplatin (Phen), pyriplatin (Pyri). Error bars represent standard error of the mean. N = 3; “****”, p < 0.0001 (p value comparison to negative control).