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. 2020 Jul 9;35(8):1797–1807. doi: 10.1093/humrep/deaa149

Figure 3.

Figure 3.

Hsa-miR-320a mimics high-quality ECM-induced migration of decidualized hESCs. (A) Endogenous miRNA is assembled into RISCs and suppress expression of target genes; miRNA mimics are likewise assembled into RISCs and suppress expression of target genes; miRNA inhibitors bind to complementary mature miRNA, thereby inhibit miRNA function. (B) Transfection of miRNA mimics and inhibitors into decidualized hESCs visualized by presence of fluorescent tags (5′-carboxyfluorescein), scale bar is 15 μm. (C) Transfection percentages of miRNA mimics and inhibitors into decidualized hESCs is not significantly different compared to negative control mimics or inhibitors. (D) Mimics for hsa-miR-320a stimulated migration of decidualized hESCs whereas all other mimics had no effect. Data are expressed as mean ± SEM. Values that are significantly different are labeled by asterisks (*P < 0.05). INH, inhibitor; ctrl, control; RISCs, RNA-induced silencing complexes.