Table 3.

Proportion of US adults with uncontrolled blood pressure (SBP ≥140 mmHg or DBP ≥90 mmHg) taking antihypertensive medication regimens in 2005–2008, 2009–2012, 2013–2016.

Number and specific antihypertensive combinations	Calendar Year
	2005–2008	2009–2012	2013–2016	P-Trend
	(n=759)	(n=964)	(n=976)	P-Trend
One Medication Class	39.3 (34.0,45.0)	42.6 (37.7,47.7)	40.2 (36.3,44.2)	0.87
ACEI or ARB	18.2 (14.3,22.8)	19.7 (15.7,24.4)	20.9 (17.9,24.2)	0.28
BB	8.0 (6.1,10.4)	10.7 (8.0,14.2)	7.1 (5.4,9.2)	0.38
Diuretic	6.5 (4.5,9.4)	4.7 (2.9,7.6)	4.9 (3.4,7.0)	0.35
CCB	5.2 (3.2,8.3)	6.1 (4.4,8.4)	6.2 (4.6,8.2)	0.52
Two Medication Classes, Any Combination	34.4 (30.8,38.3)	32.2 (28.6,36.1)	35.1 (32.3,38.0)	0.69
ACEI or ARB+Diuretic	9.9 (7.7,12.6)	8.8 (6.8,11.2)	12.8 (10.0,16.3)	0.11
ACEI or ARB+BB	6.3 (4.3,9.1)	5.9 (4.2,8.2)	5.9 (4.0,8.7)	0.87
ACEI or ARB+CCB	5.6 (3.5,8.8)	5.8 (4.4,7.6)	6.9 (5.0,9.6)	0.48
BB+Diuretic	6.3 (4.3,9.2)	6.0 (4.1,8.7)	3.8 (2.4,6.0)	0.07
CCB+Diuretic	2.1 (1.2,3.5)	1.6 (0.9,2.8)	2.0 (1.3,3.2)	1.00
BB+CCB	1.9 (1.1,3.3)	1.2 (0.6,2.3)	2.8 (1.7,4.5)	0.26
Three Medication Classes, Any Combination	20.0 (16.3,24.4)	19.7 (16.3,23.5)	19.4 (16.0,23.2)	0.80
ACEI or ARB+BB+Diuretic	7.9 (5.9,10.4)	9.0 (6.5,12.2)	5.6 (4.1,7.5)	0.05
ACEI or ARB+CCB+Diuretic	5.4 (3.6,8.0)	2.6 (1.8,3.8)	5.1 (3.0,8.5)	0.97
ACEI or ARB+BB+CCB	3.0 (1.9,4.9)	4.4 (2.8,6.8)	5.3 (3.7,7.4)	0.09
BB+CCB+Diuretic	1.4 (0.7,2.7)	1.0 (0.5,2.1)	0.8 (0.4,1.5)	0.18
Four Medication Classes, Any Combination	4.9 (3.3,7.1)	4.5 (2.8,7.0)	5.1 (3.5,7.4)	0.84
ACEI or ARB+BB+CCB+Diuretic	3.1 (0.1,1.2)	3.3 (0.0,0.5)	3.2 (0.0,0.6)	1.00
Five or More Medication Classes, Any Combination	1.4 (0.7,2.7)	1.1 (0.5,2.5)	0.3 (0.1,1.3)	0.04

Numbers in table are column percentage (95% confidence interval).

ACEI=angiotensin converting enzyme inhibitor; ARB=angiotensin-II receptor blocker; BB=beta-blocker; CCB=calcium channel blocker