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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Nat Genet. 2020 Mar 16;52(4):408–417. doi: 10.1038/s41588-020-0590-9

Figure 1: Loss-of-function CRISPR screens identify drug-induced antagonistic pleiotropy.

Figure 1:

a, Pooled drug-modifier CRISPR/Cas9 screening and API analysis strategy. CRISPR/Cas9 drug-modifier screens represented as fractions of sensitizer (red), inert (white), and resister (blue) genes. Gene cutoffs controlled by p-value of 0.05. MOI, multiplicity of infection.