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. 2020 Jul 2;12(7):e8960. doi: 10.7759/cureus.8960

Figure 1. The role of HSP70 in AMD.

Figure 1

(A) HSP70 prevents misfolding of native proteins in RPE cells which can decelerate the progression of the disease. (B) The misfolded proteins translocate to proteasome for degradation by HSP70. If proteasomal function is impaired, HSP70 machinery is stimulated and prevents the formation of protein aggregates. (C) The release of pro-inflammatory cytokines is inhibited HSP70 via inactivation of IkK. (D) HSP70 prevents aberrant apoptosis and RPE degeneration by impeding the release of pro-apoptotic factors.

AMD: age-related macular degeneration, HSP70: heat shock protein 70, RPE: retinal pigment epithelium; ikK, IkB kinase