Table 1:

Sleep SMART enrollment criteria.

Inclusion criteria

1. Age ≥18 years

2. Consent obtained within 14 days of AIS OR high risk TIA (ABCD2 score ≥4)

Exclusion criteria

1. Pre-event inability to perform all of own basic activities of daily living (ADLs)

2. Unable to obtain informed consent from subject or legally authorized representative

3. Incarcerated

4. Known pregnancy

5. Current mechanical ventilation (can enroll later if this resolves) or tracheostomy

6. Current use of positive airway pressure, or use within one month prior to stroke

7. Anatomical or dermatologic anomaly that makes use of CPAP interface unfeasible

8. Severe bullous lung disease

9. History of prior spontaneous pneumothorax or current pneumothorax

10. Hypotension requiring current treatment with pressors (can enroll later if this resolves)

11. Other specific medical circumstances that conceivably, in the opinion of the site PI, could render the patient at risk of harm from use of CPAP

12. Massive epistaxis or previous history of massive epistaxis

13. Cranial surgery or head trauma within the past 6 months, with known or possible cerebrospinal fluid (CSF) leak or pneumocephalus

14. Recent hemicraniectomy or suboccipital craniectomy (i.e. those whose bone has not yet been replaced), or any other recent bone removal procedure for relief of intracranial pressure

15. Current receipt of oxygen supplementation >4 liters per minute

16. Current contact, droplet, respiratory/airborne precautions