Table 2.
Drug characteristics and history for MA users (n = 11)
| Characteristics | Mean ± SD (Range) | |
|---|---|---|
| Age of onset (years) | 28.9 ± 16.5 (17–68) | |
| Duration of use (years) | 11.1 ± 9.70 (2–34) | |
| Frequency (days/week) | 4.84 ± 2.08 (1–7) | |
| Amount used/week (grams) | 1.81 ± 1.83 (0.1–5.3) | |
| Route of MA administration (smoked, IV, oral, nasal)* | 9, 1, 2, 2 | |
| MA Severity of Dependence Scale | 7.27 ± 2.34 | |
| Polysubstance (hair) | All MA/AM; 8 cocaine; 5 THC-COOH; 2 opiates; 1 MDMA | |
| # Marijuana users (hair) | 5 | |
| MA abstinence before PET scan (hours) | 39.2 ± 28.8 (14.3–110) | |
| Blood levels of MA/AM on PET day (nmol/ml) | 2.00 ± 2.56 (0–5.57) | |
| MA withdrawal: | ASSA (n = 8) | 55.8 ± 20.1 |
| AWQ (n = 8) | 22.9 ± 8.00 | |
| DSQ | Total | 117 ± 33.6 |
| Reinforcement | 22.0 ± 8.78 | |
| Strong desire | 26.8 ± 12.4 | |
| Mild desire | 16.0 ± 8.07 | |
| Control | 7.38 ± 3.34 |
some MA users had mulitple routes of administration
MA = methamphetamine, PET = positron emission tomography, AM = amphetamine, ASSA = Amphetamine Selective Severity Assessment, AWQ = Amphetamine Withdrawal Questionnaire, DSQ = Desire for Speed Questionnaire, AM = amphetamine, THC-COOH = 11-Nor-9-carboxy-Δ⁹-tetrahydrocannabinol, MDMA = 3,4-Methylenedioxymethamphetamine