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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: J Allergy Clin Immunol. 2020 Feb 4;146(2):390–405. doi: 10.1016/j.jaci.2020.01.038

Figure 5.

Figure 5.

Expression profile of ILC-related genes in ILC2 subpopulations by RNA-seq. FACS-sorted CRTH2+IL7Rα+ (CRTH2), CRTH2-IL7Rα+ (IL7Ra) and DN lin- cells from the peripheral blood of 4 healthy donors were used to isolate RNA and perform RNA-seq. A: Expression of genes used for sorting of ILCs (PTGDR2, IL7R), and core ILC- and NK cell-related genes (TPM: transcripts per million). B and C: Expression of genes related to ILC1 (TBX21), ILC2 (, GATA3, RORA, IRF4, GFI1, NFATC1, NFATC2, JUNB, BATF), and ILC3 (RORC and RUNX3). D-F: Expression of type-2 cytokine (IL4, IL5, and IL13) genes. G. Expression of ILC2 precursor-related genes. H and I: Top immune response genes expressed by DN cells. J and K: Top cytokine genes expressed by IL7Rα+ cells. Gene expression values are normalized to transcripts per million (TPM). Statistical significance, when present, is shown on the top of the bars.