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. 2020 Jul 22;15:5181–5202. doi: 10.2147/IJN.S247692

Table 2.

Physico-Chemical Characteristics of Nanoparticles, Modified Nanoparticles, Nanoformulations, and Combined Nanoformulations

Sample SBET (m2/g) Pore Volumea (cm3/g) Mean size Distributionb(nm) Elemental Analysisc Loading Content (wt.%)d
C% N%
MSNs 400 1.29 230 ± 15.2 5.89
MSNs-NH2 71.2 0.95 174 ± 4.6 15.06 2.93 -
MSNs-NH2-SH 64.8 0.63 211 ± 19.6 15.36 2.95 3
MSNs-NH2-QR 13.2 0.36 145 ± 6.1 20.59 2.43 22.4
MSNs-NH2-SH-QR 12.1 0.27 236 ± 18.8 21.46 2.21 24.4

Notes: aPore volume from nitrogen adsorption measurements; bmean size distribution measurements by means of NTA; camount of C and N was calculated from the elemental analysis by EDS. dDrug loading content was calculated by means of weight loss from thermogravimetric analysis: SH wt.%=MSNs-NH2-SH – MSNs-NH2*100; QR wt.% =MSNs-NH2-QR – MSNs-NH2*100; and SH-QR wt.% =MSNs-NH2-SH-QR – MSNs-NH2*100.

Abbreviations: SBET, specific surface area measured by Brunauer-Emmett-Teller; EDS, energy dispersive X-Ray spectroscopy; NTA, nanoparticle tracking analysis; MSNs, mesoporous silica nanoparticles; MSNs-NH2, MSNs modified amino groups;MSNs-NH2-SH, MSNs-NH2 loaded SH; MSNs-NH2-QR, MSNs-NH2loaded QR; MSNs-NH2-SH-QR, MSNs-NH2 loaded SH and QR; SH, shikimic acid; QR, quercetin.