Table 2.
Sample | SBET (m2/g) | Pore Volumea (cm3/g) | Mean size Distributionb(nm) | Elemental Analysisc | Loading Content (wt.%)d | |
---|---|---|---|---|---|---|
C% | N% | |||||
MSNs | 400 | 1.29 | 230 ± 15.2 | 5.89 | – | – |
MSNs-NH2 | 71.2 | 0.95 | 174 ± 4.6 | 15.06 | 2.93 | - |
MSNs-NH2-SH | 64.8 | 0.63 | 211 ± 19.6 | 15.36 | 2.95 | 3 |
MSNs-NH2-QR | 13.2 | 0.36 | 145 ± 6.1 | 20.59 | 2.43 | 22.4 |
MSNs-NH2-SH-QR | 12.1 | 0.27 | 236 ± 18.8 | 21.46 | 2.21 | 24.4 |
Notes: aPore volume from nitrogen adsorption measurements; bmean size distribution measurements by means of NTA; camount of C and N was calculated from the elemental analysis by EDS. dDrug loading content was calculated by means of weight loss from thermogravimetric analysis: SH wt.%=MSNs-NH2-SH – MSNs-NH2*100; QR wt.% =MSNs-NH2-QR – MSNs-NH2*100; and SH-QR wt.% =MSNs-NH2-SH-QR – MSNs-NH2*100.
Abbreviations: SBET, specific surface area measured by Brunauer-Emmett-Teller; EDS, energy dispersive X-Ray spectroscopy; NTA, nanoparticle tracking analysis; MSNs, mesoporous silica nanoparticles; MSNs-NH2, MSNs modified amino groups;MSNs-NH2-SH, MSNs-NH2 loaded SH; MSNs-NH2-QR, MSNs-NH2loaded QR; MSNs-NH2-SH-QR, MSNs-NH2 loaded SH and QR; SH, shikimic acid; QR, quercetin.