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. 2020 Jul 21;13:7045–7056. doi: 10.2147/OTT.S243552

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© 2020 Wang et al.

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EMX2OS inhibited proliferation, migration and invasion of DU145 cells and activated cGMP-PKG pathway. The DU145 cells were transfected with EMX2OS overexpression vector, EMX2OS siRNA and respective negative controls, following transfection for 48 h, (A) The EMX2OS overexpression and inhibition efficiencies were detected by qPCR, and cell proliferation (B), invasion (C) and migration (D) were detected with CCK-8 and Transwell assay. The protein levels of PKG1 and PKG2 (E), and the cGMP concentration (F) in supernatant were detected by Western blotting and ELISA. *p<0.05, **p<0.01.