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. 2020 Jul 21;13:7045–7056. doi: 10.2147/OTT.S243552

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© 2020 Wang et al.

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EMX2OS directly bound with FUS protein in DU145 cells. (A) The FUS binding motif was shown. (B) Schema of FUS binding sites in EMX2OS sequence. Red fonts indicated the binding motifs; blue and yellow fonts indicated the mutated nucleotides in the binding motifs. (C) Binding of EMX2OS and FUS was validated by FUS-antibody-based RNA-IP assay. (D) Binding of EMX2OS and FUS was validated by EMX2OS-probe-based RNA pull-down assay. (E) Binding of EMX2OS and FUS was validated by RNA pull-down assay using WT or MUT biotinylated EMX2OS transcripts. *p<0.05, **p<0.01, ^#p<0.05 versus MUT-both group.