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. 2020 Jul 21;13:7045–7056. doi: 10.2147/OTT.S243552

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© 2020 Wang et al.

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The effect of FUS and EMX2OS on DU145 cell behaviors was likely to be achieved via the cGMP-PKG pathway. The DU145 cells were transfected with EMX2OS and FUS overexpression vectors, following transfection for 48 h, (D)-DT-2 (2 μM) which was an inhibitor of cGMP-PKG pathway was used to treat cells for 6 h, and then the protein levels of PKG1 and PKG2 (A), and the cGMP concentration (B) in supernatant were detected by Western blotting and ELISA. Cell migration (C), invasion (D) and proliferation (E) were detected with Transwell and CCK-8 assay. *p<0.05, **p<0.01.