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. 2020 Jul 22;12:6165–6175. doi: 10.2147/CMAR.S257598

Figure 4.

Figure 4

TLR4 is a direct target of miR-145 in HCC. (A) There were targeted binding sites between miR-145 and TLR4. (B) Interaction between miR-145 and TLR4 according to the DLR assay. (C) Expression of TLR4 protein in cells transfected with miR-145-mimics, miR-145-inhibitor or corresponding miR-NC according to the WB assay, and protein bands. (D) Expression of TLR4 protein in HCC tissues and corresponding paracancerous tissues according to the qRT-PCR assay. (E) Expression of TLR4 protein in HCC tissues and corresponding paracancerous tissues according to the WB assay, and protein bands. (F) Negative correlation between miR-145 and TLR4 in HCC tissues.

Notes: **Indicates P<0.01, and ***indicates P<0.001.

Abbreviations: TLR4, toll-like receptor 4; miR, microRNA; WT, wild type; MUT, mutant type; 5-FU, 5-fluorouracil.